Development of an Experimental Model of Diabetes Co-Existing with Metabolic Syndrome in Rats
Joint Authors
Suman, Rajesh Kumar
Ray Mohanty, Ipseeta
Borde, Manjusha K.
Maheshwari, Ujwala
Deshmukh, Y. A.
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The incidence of metabolic syndrome co-existing with diabetes mellitus is on the rise globally.
Objective.
The present study was designed to develop a unique animal model that will mimic the pathological features seen in individuals with diabetes and metabolic syndrome, suitable for pharmacological screening of drugs.
Materials and Methods.
A combination of High-Fat Diet (HFD) and low dose of streptozotocin (STZ) at 30, 35, and 40 mg/kg was used to induce metabolic syndrome in the setting of diabetes mellitus in Wistar rats.
Results.
The 40 mg/kg STZ produced sustained hyperglycemia and the dose was thus selected for the study to induce diabetes mellitus.
Various components of metabolic syndrome such as dyslipidemia (increased triglyceride, total cholesterol, LDL cholesterol, and decreased HDL cholesterol), diabetes mellitus (blood glucose, HbA1c, serum insulin, and C-peptide), and hypertension {systolic blood pressure} were mimicked in the developed model of metabolic syndrome co-existing with diabetes mellitus.
In addition to significant cardiac injury, atherogenic index, inflammation (hs-CRP), decline in hepatic and renal function were observed in the HF-DC group when compared to NC group rats.
The histopathological assessment confirmed presence of edema, necrosis, and inflammation in heart, pancreas, liver, and kidney of HF-DC group as compared to NC.
Conclusion.
The present study has developed a unique rodent model of metabolic syndrome, with diabetes as an essential component.
American Psychological Association (APA)
Suman, Rajesh Kumar& Ray Mohanty, Ipseeta& Borde, Manjusha K.& Maheshwari, Ujwala& Deshmukh, Y. A.. 2016. Development of an Experimental Model of Diabetes Co-Existing with Metabolic Syndrome in Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096638
Modern Language Association (MLA)
Suman, Rajesh Kumar…[et al.]. Development of an Experimental Model of Diabetes Co-Existing with Metabolic Syndrome in Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1096638
American Medical Association (AMA)
Suman, Rajesh Kumar& Ray Mohanty, Ipseeta& Borde, Manjusha K.& Maheshwari, Ujwala& Deshmukh, Y. A.. Development of an Experimental Model of Diabetes Co-Existing with Metabolic Syndrome in Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096638