Efficacy of Continuous S(+)-Ketamine Infusion for Postoperative Pain Control: A Randomized Placebo-Controlled Trial
Joint Authors
Miziara, Luiz Eduardo de Paula Gomes
Simoni, Ricardo Francisco
Esteves, Luís Otávio
Cangiani, Luis Henrique
Grillo-Filho, Gil Fernando Ribeiro
Paula, Anderson Garcia Lima e
Source
Anesthesiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
A double-blind, randomized, placebo-controlled trial was designed to evaluate the efficacy of continuous intraoperative infusion of S(+)-ketamine under intravenous anesthesia with target-controlled infusion of remifentanil and propofol for postoperative pain control.
Methods.
Forty-eight patients undergoing laparoscopic cholecystectomy were assigned to receive continuous S(+)-ketamine infusion at a rate of 0.3 mg·kg−1·h−1 (n=24, intervention group) or an equivalent volume of saline at the same rate (n=24, placebo group).
The same target-controlled intravenous anesthesia was induced in both groups.
Pain was assessed using a 0 to 10 verbal numeric rating scale during the first 12 postoperative hours.
Pain scores and morphine consumption were recorded in the postanesthesia care unit (PACU) and at 4 and 12 hours after surgery.
Results.
Pain scores were lower in the intervention group at all time points.
Morphine consumption did not differ significantly between groups during PACU stay, but it was significantly lower in the intervention group at each time point after PACU discharge (P=0.0061).
At 12 hours after surgery, cumulative morphine consumption was also lower in the intervention group (5.200±2.707) than in the placebo group (7.525±1.872).
Conclusions.
Continuous S(+)-ketamine infusion during laparoscopic cholecystectomy under target-controlled intravenous anesthesia provided better postoperative pain control than placebo, reducing morphine requirement.
Trial Registration.
This trial is registered with ClinicalTrials.gov NCT02421913.
American Psychological Association (APA)
Miziara, Luiz Eduardo de Paula Gomes& Simoni, Ricardo Francisco& Esteves, Luís Otávio& Cangiani, Luis Henrique & Grillo-Filho, Gil Fernando Ribeiro& Paula, Anderson Garcia Lima e. 2016. Efficacy of Continuous S(+)-Ketamine Infusion for Postoperative Pain Control: A Randomized Placebo-Controlled Trial. Anesthesiology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1096674
Modern Language Association (MLA)
Miziara, Luiz Eduardo de Paula Gomes…[et al.]. Efficacy of Continuous S(+)-Ketamine Infusion for Postoperative Pain Control: A Randomized Placebo-Controlled Trial. Anesthesiology Research and Practice No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1096674
American Medical Association (AMA)
Miziara, Luiz Eduardo de Paula Gomes& Simoni, Ricardo Francisco& Esteves, Luís Otávio& Cangiani, Luis Henrique & Grillo-Filho, Gil Fernando Ribeiro& Paula, Anderson Garcia Lima e. Efficacy of Continuous S(+)-Ketamine Infusion for Postoperative Pain Control: A Randomized Placebo-Controlled Trial. Anesthesiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1096674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096674