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Comparison of Ondansetron and Dexamethasone for Prophylaxis of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgeries: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Baidya, Dalim Kumar
Som, Anirban
Maitra, Souvik
Bhattacharjee, Sulagna
Source
Anesthesiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Postoperative nausea and vomiting (PONV) is a significant complication after laparoscopic surgeries.
Ondansetron and dexamethasone are most commonly used drugs for PONV prophylaxis.
Comparisons of these two drugs have not been systematically reviewed till date.
Methods.
PubMed, PubMed Central, and CENTRAL databases were searched with the following words: “dexamethasone,” “ondansetron,” “laparoscopy,” and “PONV” to identify randomized trials that compared ondansetron and dexamethasone for PONV prophylaxis after laparoscopic surgeries.
Results.
Data of 592 patients from 7 RCTs have been included in this meta-analysis.
Incidence of postoperative nausea at 4–6 h is significantly lower when dexamethasone was used instead of ondansetron (p=0.04; OR 0.49, 95% CI 0.24–0.98, M-H fixed).
Incidence of nausea is similar at 24 hours (p=0.08, OR 0.71, 95% CI 0.48, 1.05; M-H fixed); vomiting is also similar at 4–6 h (p=0.43, OR 1.27, 95% CI 0.70–2.27; M-H fixed) and also at 24 h (p=0.46, OR 0.92, 95% CI 0.73, 1.16; M-H fixed).
Conclusion.
Dexamethasone is superior to ondansetron in preventing postoperative nausea after 4–6 h of laparoscopic surgeries.
However, both the drugs are of equal efficacy in preventing postoperative vomiting up to 24 h after surgery.
However, results should be interpreted with caution due to clinical heterogeneity in the included studies.
American Psychological Association (APA)
Maitra, Souvik& Som, Anirban& Baidya, Dalim Kumar& Bhattacharjee, Sulagna. 2016. Comparison of Ondansetron and Dexamethasone for Prophylaxis of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgeries: A Meta-Analysis of Randomized Controlled Trials. Anesthesiology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096675
Modern Language Association (MLA)
Maitra, Souvik…[et al.]. Comparison of Ondansetron and Dexamethasone for Prophylaxis of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgeries: A Meta-Analysis of Randomized Controlled Trials. Anesthesiology Research and Practice No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096675
American Medical Association (AMA)
Maitra, Souvik& Som, Anirban& Baidya, Dalim Kumar& Bhattacharjee, Sulagna. Comparison of Ondansetron and Dexamethasone for Prophylaxis of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgeries: A Meta-Analysis of Randomized Controlled Trials. Anesthesiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096675