The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia

Abstract EN

Background.

Propofol is a popular intravenous anesthetic and varieties of formulations were produced from different laboratories.

The present study compared efficacy of propofol of different laboratories and different concentrations (1 and 2%) during induction of anesthesia.

Methods.

Seventy-five scheduled surgical patients were randomly allocated into three groups.

The patients of group D1 received AstraZeneca Diprivan 1% (Osaka, Japan) at a rate of 40 mg kg−1 h−1.

Group M1 was given 1% Maruishi (Maruishi Pharmaceutical, Osaka, Japan) and group M2 was given 2% formulation at the same rate of propofol.

Achieving hypnosis was defined as failure to open their eyes in response to a verbal command and the venous blood sample was withdrawn.

Results.

The hypnotic doses of M2 were significantly larger (D1: 91.4±30.9, M1: 90.7±26.7, and M2: 118.4±40.2 mg, resp.

(mean ± SD).

p<0.005).

Age and gender were selected as statistically significant covariates using general linear model-ANOVA.

The blood concentration showed no significant difference among the groups (3.73±2.34, 4.10±3.04, and 4.70±2.12 μg mL−1, resp.).

Conclusion.

The required dose of propofol was different among the formulations; however, the serum concentration showed no significant difference.

This trial is registered with UMIN Clinical Trial Registry: UMIN000019925.