Sugammadex-Enhanced Neuronal Apoptosis following Neonatal Sevoflurane Exposure in Mice
Joint Authors
Makita, Koshi
Satomoto, Maiko
Sun, Zhongliang
Adachi, Yushi U.
Source
Anesthesiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In rodents, neonatal sevoflurane exposure induces neonatal apoptosis in the brain and results in learning deficits.
Sugammadex is a new selective neuromuscular blockade (NMB) binding agent that anesthesiologists can use to achieve immediate reversal of an NMB with few side effects.
Given its molecular weight of 2178, sugammadex is thought to be unable to pass through the blood brain barrier (BBB).
Volatile anesthetics can influence BBB opening and integrity.
Therefore, we investigated whether the intraperitoneal administration of sugammadex could exacerbate neuronal damage following neonatal 2% sevoflurane exposure via changes in BBB integrity.
Cleaved caspase-3 immunoblotting was used to detect apoptosis, and the ultrastructure of the BBB was examined by transmission electron microscopy.
Exposure to 2% sevoflurane for 6 h resulted in BBB ultrastructural abnormalities in the hippocampus of neonatal mice.
Sugammadex alone without sevoflurane did not induce apoptosis.
The coadministration of sugammadex with sevoflurane to neonatal mice caused a significant increase (150%) in neuroapoptosis in the brain compared with 2% sevoflurane.
In neonatal anesthesia, sugammadex could influence neurotoxicity together with sevoflurane.
Exposure to 2% sevoflurane for 6 h resulted in BBB ultrastructural abnormalities in the hippocampus of neonatal mice.
American Psychological Association (APA)
Satomoto, Maiko& Sun, Zhongliang& Adachi, Yushi U.& Makita, Koshi. 2016. Sugammadex-Enhanced Neuronal Apoptosis following Neonatal Sevoflurane Exposure in Mice. Anesthesiology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1096689
Modern Language Association (MLA)
Satomoto, Maiko…[et al.]. Sugammadex-Enhanced Neuronal Apoptosis following Neonatal Sevoflurane Exposure in Mice. Anesthesiology Research and Practice No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1096689
American Medical Association (AMA)
Satomoto, Maiko& Sun, Zhongliang& Adachi, Yushi U.& Makita, Koshi. Sugammadex-Enhanced Neuronal Apoptosis following Neonatal Sevoflurane Exposure in Mice. Anesthesiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1096689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096689