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Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana
Joint Authors
Obirikorang, Christian
Issahaku, Razak Gyesi
Osakunor, Derick Nii Mensah
Osei-Yeboah, James
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
We determined the prevalence of anaemia and evaluated markers of iron homeostasis in a cohort of HIV patients.
Methods.
A comparative cross-sectional study on 319 participants was carried out at the Tamale Teaching Hospital from July 2013 to December 2013, 219 patients on HAART (designated On-HAART) and 100 HAART-naive patients.
Data gathered include sociodemography, clinical history, and selected laboratory assays.
Results.
Prevalence of anaemia was 23.8%.
On-HAART participants had higher CD4/CD3 lymphocyte counts, Hb, HCT/PCV, MCV, MCH, iron, ferritin, and TSAT (P<0.05).
Hb, iron, ferritin, and TSAT decreased from grade 1 to grade 3 anaemia and CD4/CD3 lymphocyte count was lowest in grade 3 anaemia (P<0.05).
Iron (P=0.0072) decreased with disease severity whilst transferrin (P=0.0143) and TIBC (P=0.0143) increased with disease severity.
Seventy-six (23.8%) participants fulfilled the criteria for anaemia, 86 (26.9%) for iron deficiency, 41 (12.8%) for iron deficiency anaemia, and 17 (5.3%) for iron overload.
The frequency of anaemia was higher amongst participants not on HAART (OR 2.6 for grade 1 anaemia; OR 3.0 for grade 3 anaemia).
Conclusion.
In this study population, HIV-associated anaemia is common and is related to HAART status and disease progression.
HIV itself is the most important cause of anaemia and treatment of HIV should be a priority compared to iron supplementation.
American Psychological Association (APA)
Obirikorang, Christian& Issahaku, Razak Gyesi& Osakunor, Derick Nii Mensah& Osei-Yeboah, James. 2016. Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana. AIDS Research and Treatment،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096692
Modern Language Association (MLA)
Obirikorang, Christian…[et al.]. Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana. AIDS Research and Treatment No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096692
American Medical Association (AMA)
Obirikorang, Christian& Issahaku, Razak Gyesi& Osakunor, Derick Nii Mensah& Osei-Yeboah, James. Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana. AIDS Research and Treatment. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096692