Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection
Joint Authors
Knobel, Hernando
Montero, M. Milagro
Güerri-Fernández, Roberto
Sorli, Luisa
Calzado, Sonia
Horcajada, Juan Pablo
Díez-Pérez, Adolfo
Lerma, Elisabet
González, Alicia
Villar, Judith
Guelar, Ana
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hypovitaminosis D and secondary hyperparathyroidism are frequent among HIV-infected patients.
As there are no data about the best supplementation therapy both in treatment and in maintenance, we conducted an observational study of 300 HIV-infected patients for whom vitamin D and parathormone (PTH) had been measured in order to validate a protocol of vitamin D supplementation in patients with HIV-infection.
Patients with vitamin D deficiency (defined as 25(OH)D < 10 ng/mL), insufficiency (defined as 25(OH)D < 20 ng/mL), or hyperparathyroidism (PTH > 65 pg/mL) were supplemented with cholecalciferol 16.000IU (0.266 mg) weekly (if deficiency) or fortnightly (if insufficiency or high PTH levels).
Rates of normalization of 25(OH)D (levels above 20 ng/mL) and PTH levels (<65 pg/mL) were analyzed.
Multivariate analysis of factors related to normalization was carried out.
With a median follow-up of 2 years, 82.1% of patients with deficiency and 83.9% of cases with insufficiency reached levels above 20 ng/mL.
However, only 67.2% of individuals with hyperparathyroidism at baseline reached target levels (<65 pg/mL).
Independent factors for not achieving PTH objective were tenofovir (TDF) and protease inhibitors use.
In HIV-infected patients with hypovitaminosis, the protocol of cholecalciferol supplementation normalized vitamin D levels regardless of antiretroviral regimen in a high proportion of patients but it was less effective to correct hyperparathyroidism.
American Psychological Association (APA)
Lerma, Elisabet& Güerri-Fernández, Roberto& Villar, Judith& González, Alicia& Guelar, Ana& Montero, M. Milagro…[et al.]. 2016. Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection. AIDS Research and Treatment،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096705
Modern Language Association (MLA)
Lerma, Elisabet…[et al.]. Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection. AIDS Research and Treatment No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096705
American Medical Association (AMA)
Lerma, Elisabet& Güerri-Fernández, Roberto& Villar, Judith& González, Alicia& Guelar, Ana& Montero, M. Milagro…[et al.]. Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection. AIDS Research and Treatment. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096705