![](/images/graphics-bg.png)
Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model
Joint Authors
Cheresiz, S. V.
Semenova, E. A.
Chepurnov, A. A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Establishment of small animal models of Ebola virus (EBOV) infection is important both for the study of genetic determinants involved in the complex pathology of EBOV disease and for the preliminary screening of antivirals, production of therapeutic heterologic immunoglobulins, and experimental vaccine development.
Since the wild-type EBOV is avirulent in rodents, the adaptation series of passages in these animals are required for the virulence/lethality to emerge in these models.
Here, we provide an overview of our several adaptation series in guinea pigs, which resulted in the establishment of guinea pig-adapted EBOV (GPA-EBOV) variants different in their characteristics, while uniformly lethal for the infected animals, and compare the virologic, genetic, pathomorphologic, and immunologic findings with those obtained in the adaptation experiments of the other research groups.
American Psychological Association (APA)
Cheresiz, S. V.& Semenova, E. A.& Chepurnov, A. A.. 2016. Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model. Advances in Virology،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1096778
Modern Language Association (MLA)
Cheresiz, S. V.…[et al.]. Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model. Advances in Virology No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1096778
American Medical Association (AMA)
Cheresiz, S. V.& Semenova, E. A.& Chepurnov, A. A.. Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model. Advances in Virology. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1096778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096778