Polyanionic Biopolymers for the Delivery of Pt(II) Cationic Antiproliferative Complexes
Joint Authors
Ravera, Mauro
Gabano, Elisabetta
Zanellato, Ilaria
Perin, Elena
Arrais, Aldo
Osella, Domenico
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Phenanthriplatin, that is, (SP-4-3)-diamminechlorido(phenanthridine)platinum(II) nitrate, an effective antitumor cationic Pt(II) complex, was loaded on negatively charged dextran sulfate (DS) as a model vector for drug delivery via electrostatic interactions.
The free complex and the corresponding conjugate with DS were tested on two standard human tumor cell lines, namely, ovarian A2780 and colon HCT 116, and on several malignant pleural mesothelioma cell lines (namely, epithelioid BR95, mixed/biphasic MG06, sarcomatoid MM98, and sarcomatoid cisplatin-resistant MM98R).
The in vitro results suggest that the conjugate releases the active metabolite phenanthriplatin with a biphasic fashion.
In these experimental conditions, the conjugate is slightly less active than free phenanthriplatin; but both exhibited antiproliferative potency higher than the reference metallodrug cisplatin and were able to overcome the acquired cisplatin chemoresistance in MM98R cells.
American Psychological Association (APA)
Ravera, Mauro& Gabano, Elisabetta& Zanellato, Ilaria& Perin, Elena& Arrais, Aldo& Osella, Domenico. 2016. Polyanionic Biopolymers for the Delivery of Pt(II) Cationic Antiproliferative Complexes. Bioinorganic Chemistry and Applications،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096784
Modern Language Association (MLA)
Ravera, Mauro…[et al.]. Polyanionic Biopolymers for the Delivery of Pt(II) Cationic Antiproliferative Complexes. Bioinorganic Chemistry and Applications No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096784
American Medical Association (AMA)
Ravera, Mauro& Gabano, Elisabetta& Zanellato, Ilaria& Perin, Elena& Arrais, Aldo& Osella, Domenico. Polyanionic Biopolymers for the Delivery of Pt(II) Cationic Antiproliferative Complexes. Bioinorganic Chemistry and Applications. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096784