A Novel Application of Ti-Substituted Polyoxometalates: Anti-Inflammatory Activity in OVA-Induced Asthma Murine Model
Joint Authors
Li, Dong
Gao, Xiuzhu
Gu, Jingmin
Tian, Yuan
Liu, Yaqing
Jin, Zheng
Yan, Dongmei
Chen, Ya-Guang
Zhu, Xun
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Asthma is a chronic inflammatory disorder.
Despite extensive researches into the treatment and management of it, current treatments and management strategies are still limited.
The search for a novel approach to its treatments is urgently needed.
Researches on the potential medical use of polyoxometalates (POMs) have already shown it has antiviral and antitumor bioactivities.
But the effects of POM in immune systems are still largely unknown.
Methods.
In order to investigate the role of POM in the asthmatic disease, we used OVA-induced asthma murine model and observed the pathological changes between mice that received three different Ti-substituted POMs (0.3 μg per mouse per dose) when challenged with OVA.
We also measured the type 2 cytokine expressions to reveal the potential mechanism.
Results and Conclusions.
Our results showed that two Ti-substituted POMs, K5H2[FeW11TiO40]·17H2O and K5H[H2ZnW11TiO40]·35H2O, could reduce OVA-induced lung inflammation, serum IgE level (around 2000 ng/mL to less than 1000 ng/mL), leukocytes infiltration in the lung, and cytokines levels (including IL-4, IL-5, IL-13, and TNF-α) but Ti-centered POM K4[TiW12O40]·10H2O did not.
Thus, Ti-substituted POMs may have pharmaceutical values especially in treatments for asthmatic diseases.
American Psychological Association (APA)
Li, Dong& Gao, Xiuzhu& Gu, Jingmin& Tian, Yuan& Liu, Yaqing& Jin, Zheng…[et al.]. 2016. A Novel Application of Ti-Substituted Polyoxometalates: Anti-Inflammatory Activity in OVA-Induced Asthma Murine Model. Bioinorganic Chemistry and Applications،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096787
Modern Language Association (MLA)
Li, Dong…[et al.]. A Novel Application of Ti-Substituted Polyoxometalates: Anti-Inflammatory Activity in OVA-Induced Asthma Murine Model. Bioinorganic Chemistry and Applications No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1096787
American Medical Association (AMA)
Li, Dong& Gao, Xiuzhu& Gu, Jingmin& Tian, Yuan& Liu, Yaqing& Jin, Zheng…[et al.]. A Novel Application of Ti-Substituted Polyoxometalates: Anti-Inflammatory Activity in OVA-Induced Asthma Murine Model. Bioinorganic Chemistry and Applications. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096787