Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruzi Activity
Joint Authors
Soeiro, Maria de Nazaré C.
Martins, Darliane A.
Gouvea, Ligiane R.
Muniz, Gabriel S. Vignoli
Louro, Sonia R. W.
Teixeira, Letícia R.
Batista, Denise G. J.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Copper(II) complexes with the first-generation quinolone antibacterial agent norfloxacin containing a nitrogen donor heterocyclic ligand 2,2′-bipyridine (bipy) or 1,10-phenanthroline (phen) were prepared and characterized by IR, EPR spectra, molar conductivity, and elemental analyses.
The experimental data suggest that norfloxacin was coordinated to copper(II) through the carboxylato and ketone oxygen atoms.
The interaction of the copper(II) complexes with bovine serum albumin (BSA) and human serum albumin (HSA) was investigated using fluorescence quenching of the tryptophan residues and copper(II) EPR spectroscopy.
The results of fluorescence titration revealed that copper(II) complexes have a moderate ability to quench the intrinsic fluorescence of the albumins through a static quenching mechanism.
EPR experiments showed that BSA and HSA Cu(II) sites compete with NOR for Cu(II)-bipy and Cu(II)-phen to form protein mixed-ligand complexes.
Copper(II) complexes, together with the corresponding ligands, were evaluated for their trypanocidal activity in vitro against Trypanosoma cruzi, the causative agent of Chagas disease.
The tests performed using bloodstream trypomastigotes showed that the Cu(II)-N-donor precursors and the metal complexes were more active than the free fluoroquinolone.
American Psychological Association (APA)
Martins, Darliane A.& Gouvea, Ligiane R.& Muniz, Gabriel S. Vignoli& Louro, Sonia R. W.& Batista, Denise G. J.& Soeiro, Maria de Nazaré C.…[et al.]. 2016. Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruzi Activity. Bioinorganic Chemistry and Applications،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096793
Modern Language Association (MLA)
Martins, Darliane A.…[et al.]. Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruzi Activity. Bioinorganic Chemistry and Applications No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1096793
American Medical Association (AMA)
Martins, Darliane A.& Gouvea, Ligiane R.& Muniz, Gabriel S. Vignoli& Louro, Sonia R. W.& Batista, Denise G. J.& Soeiro, Maria de Nazaré C.…[et al.]. Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruzi Activity. Bioinorganic Chemistry and Applications. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096793