Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA
Joint Authors
Tan, Mingxiong
Zhong, Yi-ning
Zhang, Yan
Gu, Yun-qiong
Wu, Shi-yun
Shen, Wen-ying
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Tryptanthrin is one of the most important members of indoloquinoline alkaloids.
We obtained this alkaloid from Isatis.
Two novel FeII and CoII complexes of tryptanthrin were first synthesized.
Single-crystal X-ray diffraction analyses show that these complexes display distorted four-coordinated tetrahedron geometry via two heterocyclic nitrogen and oxygen atoms from tryptanthrin ligand.
Binding with G-quadruplex DNA properties revealed that both complexes were found to exhibit significant interaction with G-quadruplex DNA.
This study may potentially serve as the basis of future rational design of metal-based drugs from natural products that target the G-quadruplex DNA.
American Psychological Association (APA)
Zhong, Yi-ning& Zhang, Yan& Gu, Yun-qiong& Wu, Shi-yun& Shen, Wen-ying& Tan, Mingxiong. 2016. Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA. Bioinorganic Chemistry and Applications،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096794
Modern Language Association (MLA)
Zhong, Yi-ning…[et al.]. Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA. Bioinorganic Chemistry and Applications No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096794
American Medical Association (AMA)
Zhong, Yi-ning& Zhang, Yan& Gu, Yun-qiong& Wu, Shi-yun& Shen, Wen-ying& Tan, Mingxiong. Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA. Bioinorganic Chemistry and Applications. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096794