In Vivo Radionuclide Generators for Diagnostics and Therapy
Joint Authors
Kjaer, Andreas
Edem, Patricia E.
Fonslet, Jesper
Herth, Matthias
Severin, Gregory
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy.
Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb to execute a targeted delivery of the therapeutic short-lived α-emitter 212Bi.
Often, as in the case of 81Rb/81Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value.
In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences.
This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research.
This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.
American Psychological Association (APA)
Edem, Patricia E.& Fonslet, Jesper& Kjaer, Andreas& Herth, Matthias& Severin, Gregory. 2016. In Vivo Radionuclide Generators for Diagnostics and Therapy. Bioinorganic Chemistry and Applications،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096798
Modern Language Association (MLA)
Edem, Patricia E.…[et al.]. In Vivo Radionuclide Generators for Diagnostics and Therapy. Bioinorganic Chemistry and Applications No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096798
American Medical Association (AMA)
Edem, Patricia E.& Fonslet, Jesper& Kjaer, Andreas& Herth, Matthias& Severin, Gregory. In Vivo Radionuclide Generators for Diagnostics and Therapy. Bioinorganic Chemistry and Applications. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096798