Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases
Joint Authors
Ejidike, Ikechukwu P.
Ajibade, Peter A.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mononuclear Ru(III) complexes of the type [Ru(LL)Cl2(H2O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N′-(2- { ( E ) -[1-(2,4-dihydroxyphenyl)ethylidene] a m i n o } ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N- { 2 -[(Z)-(4-hydroxy-3-methoxybenzylidene)amino] e t h y l } ethanimidoyl]benzene-1,3-diol [HME], 4-[(1E)-N- { 2 -[(Z)-(3,4-dimethoxybenzylidene)amino] e t h y l } ethanimidoyl]benzene-1,3-diol [MBE], and N-(2- { ( E ) -[1-(2,4-dihydroxyphenyl)ethylidene] a m i n o } ethyl)benzenecarboximidoyl chloride [DEE]) were synthesized and characterized using the microanalytical, conductivity measurements, electronic spectra, and FTIR spectroscopy.
IR spectral studies confirmed that the ligands act as tridentate chelate coordinating the metal ion through the azomethine nitrogen and phenolic oxygen atom.
An octahedral geometry has been proposed for all Ru(III)-Schiff base complexes.
In vitro anticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay.
[Ru(DAE)Cl2(H2O)] showed the highest activity with IC50 valves of 3.57 ± 1.09 , 6.44 ± 0.38 , and 9.06 ± 1.18 μM against MCF-7, UACC-62, and TK-10, respectively, order of activity being TK-10 < UACC-62 < MCF-7.
The antioxidant activity by DPPH and ABTS inhibition assay was also examined.
Scavenging ability of the complexes on DPPH radical can be ranked in the following order: [Ru(DEE)Cl2(H2O)] > [Ru(HME)Cl2(H2O)] > [Ru(DAE)Cl2(H2O)] > [Ru(MBE)Cl2(H2O)].
American Psychological Association (APA)
Ejidike, Ikechukwu P.& Ajibade, Peter A.. 2016. Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases. Bioinorganic Chemistry and Applications،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096807
Modern Language Association (MLA)
Ejidike, Ikechukwu P.& Ajibade, Peter A.. Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases. Bioinorganic Chemistry and Applications No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1096807
American Medical Association (AMA)
Ejidike, Ikechukwu P.& Ajibade, Peter A.. Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases. Bioinorganic Chemistry and Applications. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096807