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The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis
Joint Authors
Rass, Anwar A.
Talat, Mohamed A.
Arafa, Mohamed A.
El-Saadany, Hosam F.
Amin, Ezzat K.
Abdelsalam, Mohamed Mohamed
Mansour, Mona A.
Khalifa, Naglaa A.
Kamel, Lamiaa Mahmoud
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Early diagnosis and treatment of neonatal sepsis may help decrease neonatal mortality.
Aim of the Study.
To evaluate the role of pancreatic stone protein as a marker for early onset neonatal sepsis.
Methods.
A hospital-based prospective study was conducted on 104 (52 uninfected and 52 infected neonates) admitted to the Neonatal Intensive Care Unit (NICU) of Zagazig University hospitals during the period from April 2014 to April 2015.
All newborns were subjected to full history taking, careful neonatal assessment, blood, C-reactive protein (CRP), and serum pancreatic stone protein.
Results.
Serum PSP levels were significantly higher in the infected group than in the uninfected group.
At a cutoff level of PSP 12.96 ng/mL, the sensitivity was 96.2%, the specificity was 88.5%, positive predictive value was 95.8%, negative predictive value was 89.3%, and area under the curve was 0.87.
A significant positive correlation between CRP and PSP was found in infected group.
Conclusion.
The high negative predictive value of PSP (89.3%) indicates that the serum PSP level is a good marker for diagnosis of early onset neonatal sepsis and can be used to limit hospital stay and antibiotic use in neonates treated for suspected sepsis.
American Psychological Association (APA)
Rass, Anwar A.& Talat, Mohamed A.& Arafa, Mohamed A.& El-Saadany, Hosam F.& Amin, Ezzat K.& Abdelsalam, Mohamed Mohamed…[et al.]. 2016. The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096810
Modern Language Association (MLA)
Rass, Anwar A.…[et al.]. The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096810
American Medical Association (AMA)
Rass, Anwar A.& Talat, Mohamed A.& Arafa, Mohamed A.& El-Saadany, Hosam F.& Amin, Ezzat K.& Abdelsalam, Mohamed Mohamed…[et al.]. The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096810