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Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-κB Signaling
Joint Authors
Wang, Liwen
Fang, Lianying
Zhi, Dexian
Wang, Suying
Zhao, Hui
Yue, Zhiwei
Guo, Mengzheng
Bai, Liang
Li, Xinyu
Tao, Yongqing
Liu, Qiang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hyperoside, an active compound found in plants of the genera Hypericum and Crataegus, is reported to exhibit antioxidant, anticancer, and anti-inflammatory activities.
Induction of hepatic stellate cell (HSC) apoptosis is recognized as a promising strategy for attenuation of hepatic fibrosis.
In this study, we investigated whether hyperoside treatment can exert antifibrotic effects in human LX-2 hepatic stellate cells.
We found that hyperoside induced apoptosis in LX-2 cells and decreased levels of α-smooth muscle actin (α-SMA), type I collagen, and intracellular reactive oxygen species (ROS).
Remarkably, hyperoside also inhibited the DNA-binding activity of the transcription factor NF-κB and altered expression levels of NF-κB-regulated genes related to apoptosis, including proapoptotic genes Bcl-Xs, DR4, Fas, and FasL and anti-apoptotic genes A20, c-IAP1, Bcl-XL, and RIP1.
Our results suggest that hyperoside may have potential as a therapeutic agent for the treatment of liver fibrosis.
American Psychological Association (APA)
Wang, Liwen& Yue, Zhiwei& Guo, Mengzheng& Fang, Lianying& Bai, Liang& Li, Xinyu…[et al.]. 2016. Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-κB Signaling. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096818
Modern Language Association (MLA)
Wang, Liwen…[et al.]. Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-κB Signaling. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1096818
American Medical Association (AMA)
Wang, Liwen& Yue, Zhiwei& Guo, Mengzheng& Fang, Lianying& Bai, Liang& Li, Xinyu…[et al.]. Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-κB Signaling. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096818