Differences in Dry Eye Questionnaire Symptoms in Two Different Modalities of Contact Lens Wear: Silicone-Hydrogel in Daily Wear Basis and Overnight Orthokeratology

Abstract EN

Purpose.

To compare the ocular surface symptoms and signs in an adult population of silicone-hydrogel (Si-Hy) contact lens (CL) wearers with another modality of CL wear, overnight orthokeratology (OK).

Materials and Methods.

This was a prospective and comparative study in which 31 myopic subjects were fitted with the same Si-Hy CL and 23 underwent OK treatment for 3 months.

Dry eye questionnaire (DEQ) was filled in at the beginning of the study and then after 15 days, 1 month, and 3 months using each CL modality.

The tear quality was evaluated with noninvasive tear break-up time.

Tear production was measured with Schirmer test.

Tear samples were collected with Schirmer strips being frozen to analyze the dinucleotide diadenosine tetraphosphate (Ap4A) concentration with High-Performance Liquid Chromatography (HPLC).

Results.

After refitting with ortho-k, a reduction in discomfort and dryness symptoms at the end of the day ( p < 0.05 , χ 2 ) was observed.

No significant changes were observed in Ap4A concentration in any group.

Bulbar redness, limbal redness, and conjunctival staining increased significantly in the Si-Hy group ( p < 0.05 , Kruskal–Wallis test).

Conclusion.

Discomfort and dryness symptoms at the end of the day are lower in the OK CL group than in the Si-Hy CL group.