Therapeutic Strategies in HCC: Radiation Modalities

Joint Authors

Storto, Giovanni
Gallicchio, R.
Nardelli, A.
Mainenti, P.
Nappi, A.
Capacchione, D.
Simeon, V.
Sirignano, C.
Abbruzzi, F.
Barbato, F.
Landriscina, M.

Source

BioMed Research International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-08-03

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

Patients with hepatocellular carcinoma (HCC) comply with an advanced disease and are not eligible for radical therapy.

In this distressed scenario new treatment options hold great promise; among them transarterial chemoembolization (TACE) and transarterial metabolic radiotherapy (TAMR) have shown efficacy in terms of both tumor shrinking and survival.

External radiation therapy (RTx) by using novel three-dimensional conformal radiotherapy has also been used for HCC patients with encouraging results while its role had been limited in the past for the low tolerance of surrounding healthy liver.

The rationale of TAMR derives from the idea of delivering exceptional radiation dose locally to the tumor, with cell killing intent, while preserving normal liver from undue exposition and minimizing systemic irradiation.

Since the therapeutic efficacy of TACE is being continuously disputed, the TAMR with 131I Lipiodol or 90Y microspheres has gained consideration providing adequate therapeutic responses regardless of few toxicities.

The implementation of novel radioisotopes and technological innovations in the field of RTx constitutes an intriguing field of research with important translational aspects.

Moreover, the combination of different therapeutic approaches including chemotherapy offers captivating perspectives.

We present the role of the radiation-based therapies in hepatocellular carcinoma patients who are not entitled for radical treatment.

American Psychological Association (APA)

Gallicchio, R.& Nardelli, A.& Mainenti, P.& Nappi, A.& Capacchione, D.& Simeon, V.…[et al.]. 2016. Therapeutic Strategies in HCC: Radiation Modalities. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096846

Modern Language Association (MLA)

Gallicchio, R.…[et al.]. Therapeutic Strategies in HCC: Radiation Modalities. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1096846

American Medical Association (AMA)

Gallicchio, R.& Nardelli, A.& Mainenti, P.& Nappi, A.& Capacchione, D.& Simeon, V.…[et al.]. Therapeutic Strategies in HCC: Radiation Modalities. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096846

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1096846