Polymorphism of 41 kD Flagellin Gene and Its Human B-Cell Epitope in Borrelia burgdorferi Strains of China
Joint Authors
Liu, Huixin
Liu, Wei
Hou, Xuexia
Zhang, Lin
Hao, Qin
Wan, Kanglin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The 41 kD flagellin of Borrelia burgdorferi (B.
burgdorferi) is a major component of periplasmic flagellar filament core and a good candidate for serodiagnosis in early stage of Lyme disease.
Here, we chose 89 B.
burgdorferi strains in China, amplified the gene encoding the 41 kD flagellin, and compared the sequences.
The results showed that genetic diversity presented in the 41 kD flagellin genes of all 89 strains among the four genotypes of B.
burgdorferi, especially in the genotype of B.
garinii.
Some specific mutation sites for each genotype of the 41 kD flagellin genes were found, which could be used for genotyping B.
burgdorferi strains in China.
Human B-cell epitope analysis showed that thirteen of 15 nonsynonymous mutations occurred in the epitope region of 41 kD flagellin and thirty of 42 B-cell epitopes were altered due to all 13 nonsynonymous mutations in the epitope region, which may affect the function of the antigen.
Nonsynonymous mutations and changed human B-cell epitopes exist in 41 kD flagellin of B.
burgdorferi sensu lato strains; these changes should be considered in serodiagnosis of Lyme disease.
American Psychological Association (APA)
Liu, Huixin& Liu, Wei& Hou, Xuexia& Zhang, Lin& Hao, Qin& Wan, Kanglin. 2016. Polymorphism of 41 kD Flagellin Gene and Its Human B-Cell Epitope in Borrelia burgdorferi Strains of China. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096855
Modern Language Association (MLA)
Liu, Huixin…[et al.]. Polymorphism of 41 kD Flagellin Gene and Its Human B-Cell Epitope in Borrelia burgdorferi Strains of China. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096855
American Medical Association (AMA)
Liu, Huixin& Liu, Wei& Hou, Xuexia& Zhang, Lin& Hao, Qin& Wan, Kanglin. Polymorphism of 41 kD Flagellin Gene and Its Human B-Cell Epitope in Borrelia burgdorferi Strains of China. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096855