First Report of Eurycoma longifolia Jack Root Extract Causing Relaxation of Aortic Rings in Rats
Joint Authors
Tee, Bae Huey
Cheah, Swee Hung
Lam, Sau Kuen
Hoe, See Ziau
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although Eurycoma longifolia has been studied for erectile function, the blood pressure- (BP-) lowering effect has yet to be verified.
Hence, this study aims at investigating the BP-lowering properties of the plant with a view to develop an antihypertensive agent that could also preserve erectile function.
Ethanolic root extract was partitioned by hexane, dichloromethane (DCM), ethyl acetate, butanol, and water.
The DCM fraction, found to be potent in relaxing phenylephrine- (PE-) precontracted rat aortic rings, was further purified by column chromatography.
Subfraction DCM-II, being the most active in relaxing aortae, was studied for effects on the renin-angiotensin and kallikrein-kinin systems in aortic rings.
The effect of DCM-II on angiotensin-converting enzyme (ACE) activity was also evaluated in vitro.
Results showed that DCM-II reduced ( p < 0.05 ) the contractions evoked by angiotensin I and angiotensin II (Ang II).
In PE-precontracted rings treated with DCM-II, the Ang II-induced contraction was attenuated ( p < 0.05 ) while bradykinin- (BK-) induced relaxation enhanced ( p < 0.001 ).
In vitro, DCM-II inhibited ( p < 0.001 ) the activity of ACE.
These data demonstrate that the vasodilatory effect of DCM-II appears to be mediated via inhibition of Ang II type 1 receptor and ACE as well as enhancement of Ang II type 2 receptor activation and BK activity.
American Psychological Association (APA)
Tee, Bae Huey& Hoe, See Ziau& Cheah, Swee Hung& Lam, Sau Kuen. 2016. First Report of Eurycoma longifolia Jack Root Extract Causing Relaxation of Aortic Rings in Rats. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096860
Modern Language Association (MLA)
Tee, Bae Huey…[et al.]. First Report of Eurycoma longifolia Jack Root Extract Causing Relaxation of Aortic Rings in Rats. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1096860
American Medical Association (AMA)
Tee, Bae Huey& Hoe, See Ziau& Cheah, Swee Hung& Lam, Sau Kuen. First Report of Eurycoma longifolia Jack Root Extract Causing Relaxation of Aortic Rings in Rats. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096860