Influence of APOE Genotype on Alzheimer’s Disease CSF Biomarkers in a Spanish Population
Joint Authors
Gasparini Berenguer, Ruth
Gutierrez-Agulló, M.
Leiva-Santana, Carlos
Sánchez-Payá, José
Muñoz-Ruiz, Carlos
Monge-Argilés, Jose Antonio
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To evaluate the association between apolipoprotein E (APOE) genotype and cerebrospinal fluid (CSF) levels of Alzheimer’s disease (AD) biomarkers and to study the influence of APOE genotype on the development of AD in a Spanish population.
Material and Methods.
The study comprised 29 amnestic mild cognitive impairment (MCI) patients and 27 control subjects.
Using ELISA methodology, CSF biomarkers and tau/Aβ ratios were obtained.
ANOVA and adjusted odds ratios were calculated.
Results.
We observed the effect of APOE genotype and age on CSF AD variables.
The progression to AD was more clearly influenced by CSF AD variables than by age or APOE status.
Conclusions.
APOE status influences CSF AD variables.
However, the presence of APOE ε4 does not appear to be a deterministic factor for the development of AD, because CSF variables have a greater influence on progression to the disease.
These results confirm previous observations and, to our knowledge, are the first published in a Spanish population.
American Psychological Association (APA)
Monge-Argilés, Jose Antonio& Gasparini Berenguer, Ruth& Gutierrez-Agulló, M.& Muñoz-Ruiz, Carlos& Sánchez-Payá, José& Leiva-Santana, Carlos. 2016. Influence of APOE Genotype on Alzheimer’s Disease CSF Biomarkers in a Spanish Population. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096867
Modern Language Association (MLA)
Monge-Argilés, Jose Antonio…[et al.]. Influence of APOE Genotype on Alzheimer’s Disease CSF Biomarkers in a Spanish Population. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096867
American Medical Association (AMA)
Monge-Argilés, Jose Antonio& Gasparini Berenguer, Ruth& Gutierrez-Agulló, M.& Muñoz-Ruiz, Carlos& Sánchez-Payá, José& Leiva-Santana, Carlos. Influence of APOE Genotype on Alzheimer’s Disease CSF Biomarkers in a Spanish Population. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096867