Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer
Joint Authors
Mcilhatton, Michael A.
Boivin, Gregory P.
Groden, Joanna
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-20
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Technical and biological innovations have enabled the development of more sophisticated and focused murine models that increasingly recapitulate the complex pathologies of human diseases, in particular cancer.
Mouse models provide excellent in vivo systems for deciphering the intricacies of cancer biology within the context of precise experimental settings.
They present biologically relevant, adaptable platforms that are amenable to continual improvement and refinement.
We discuss how recent advances in our understanding of tumorigenesis and the underlying deficiencies of DNA repair mechanisms that drive it have been informed by using genetically engineered mice to create defined, well-characterized models of human colorectal cancer.
In particular, we focus on how mechanisms of DNA repair can be manipulated precisely to create in vivo models whereby the underlying processes of tumorigenesis are accelerated or attenuated, dependent on the composite alleles carried by the mouse model.
Such models have evolved to the stage where they now reflect the initiation and progression of sporadic cancers.
The review is focused on mouse models of colorectal cancer and how insights from these models have been instrumental in shaping our understanding of the processes and potential therapies for this disease.
American Psychological Association (APA)
Mcilhatton, Michael A.& Boivin, Gregory P.& Groden, Joanna. 2016. Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer. BioMed Research International،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1096872
Modern Language Association (MLA)
Mcilhatton, Michael A.…[et al.]. Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer. BioMed Research International No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1096872
American Medical Association (AMA)
Mcilhatton, Michael A.& Boivin, Gregory P.& Groden, Joanna. Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1096872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096872