Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension
Joint Authors
Zhang, Lina
Gu, Tianlun
Mao, Shuqi
Fan, Rui
Zhong, Fade
Zhu, Fubao
Hao, Lingmei
Yin, Fengying
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aldosterone synthase (CYP11B2) is closely linked to essential hypertension (EH).
However, it remains unclear whether the methylation of the CYP11B2 promoter is involved in the development of EH in humans.
Our study is aimed at evaluating the contribution of CYP11B2 promoter methylation to the risk of EH.
Methylation levels were measured using pyrosequencing technology in 192 participants in a hospital-based case-control study.
Logistic regression and multiple linear regression analyses were utilized to adjust for confounding factors and the GMDR method was applied to investigate high-order gene-environment interactions.
Although no significant result was observed linking the four analyzed CpG sites to EH, GMDR detected significant interactions among CpG1, CpG3, CpG4, and smoking correlated with an increased risk of EH (OR = 4.62, adjusted P=0.011).
In addition, CpG2 (adjusted P=0.013) and CpG3 (adjusted P=0.039) methylation was significantly lower in healthy males than in healthy females.
Likewise, after adjusting for confounding factors, CpG2 methylation (adjusted P=0.007) still showed significant gender-specific differences among the participants of the study.
CpG1 (P=0.009) site was significantly positively correlated with age, and CpG3 (P=0.007) and CpG4 (P=0.006) were both inversely linked to smoking.
Our findings suggest that gene-environment interactions are associated with the pathogenesis and progression of EH.
American Psychological Association (APA)
Gu, Tianlun& Mao, Shuqi& Fan, Rui& Zhong, Fade& Zhu, Fubao& Hao, Lingmei…[et al.]. 2016. Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096885
Modern Language Association (MLA)
Gu, Tianlun…[et al.]. Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096885
American Medical Association (AMA)
Gu, Tianlun& Mao, Shuqi& Fan, Rui& Zhong, Fade& Zhu, Fubao& Hao, Lingmei…[et al.]. Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096885