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Vaccination with Astragalus and Ginseng Polysaccharides Improves Immune Response of Chickens against H5N1 Avian Influenza Virus
Joint Authors
Li, Guoqing
Yu, Xingang
Abullahi, Auwalu Yusuf
Kallon, Sanpha
Zhang, Yongliang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To determine the effect of astragalus and ginseng polysaccharides (APS, GPS) on immune response and improvement of H5N1 vaccine, 360-day-old broilers were randomly divided into 8 groups of 45 chicks, comprising APS groups (1–3); GPS groups (4–6); vaccine group (7); and blank control (8) (without polysaccharide and vaccine).
From day 12 after hatch groups 1–3 were given APS and groups 4–6 with GPS both at 100, 200, and 400 (mg/kg), respectively.
At day 15 after hatch, groups 1–7 were vaccinated with 0.3 mL H5N1 vaccine subcutaneously; daily weight gain (DWG) and serum Ig antibody (by HI-test) were measured on 3, 7, 14, and 28 days after vaccination.
Serum antibody titers and expression of cytokines (IL-2, IL-10, I FN-γ, and TNF) were determined by ELISA and RT-PCR.
Results revealed that all the polysaccharide groups were numerically increased in antibody levels and the expression of cytokines was significant (P<0.05) in the APS and GPS groups compared to corresponding vaccine group and blank control.
DWG was higher (P<0.05) in 400 mg/kg APS groups than control groups.
Thus oral supplements of GPS and APS have shown their potential in the improvement of immune response and could be used as adjuvant in a formulation of H5N1 vaccine.
American Psychological Association (APA)
Abullahi, Auwalu Yusuf& Kallon, Sanpha& Yu, Xingang& Zhang, Yongliang& Li, Guoqing. 2016. Vaccination with Astragalus and Ginseng Polysaccharides Improves Immune Response of Chickens against H5N1 Avian Influenza Virus. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096905
Modern Language Association (MLA)
Abullahi, Auwalu Yusuf…[et al.]. Vaccination with Astragalus and Ginseng Polysaccharides Improves Immune Response of Chickens against H5N1 Avian Influenza Virus. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096905
American Medical Association (AMA)
Abullahi, Auwalu Yusuf& Kallon, Sanpha& Yu, Xingang& Zhang, Yongliang& Li, Guoqing. Vaccination with Astragalus and Ginseng Polysaccharides Improves Immune Response of Chickens against H5N1 Avian Influenza Virus. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096905