Association between the Achievement of Target Range CKD-MBD Markers and Mortality in Prevalent Hemodialysis Patients in Taiwan by Using the Kidney Disease: Improving Global Outcomes Clinical Guidelines
Joint Authors
Cheng, Ben-Chung
Li, Lung-Chih
Lee, Wen-Chin
Liu, Ying
Lee, Chih-Hsiung
Chang, Wen-Xiu
Chen, Jin-Bor
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
This study evaluated the association between achieving target chronic kidney disease-mineral and bone disorder (CKD-MBD) marker levels and mortality in Taiwanese hemodialysis (HD) patients.
Target levels were based on the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.
Methods.
We performed a retrospective medical record review of 1126 HD patients between 2009 and 2013.
A logistic regression model was used to evaluate the relationship between achieving target marker levels and the risk for all-cause and cardiovascular (CV) mortality.
Reference target ranges were 7.9 ≤ calcium (Ca) ≤ 9.9 mg/dL, 2.4 ≤ phosphate (P) ≤ 4.7 mg/dL, and 144 ≤ intact parathyroid hormone (iPTH) ≤ 648 pg/mL.
Results.
Achievement of target P levels was associated with a lower risk for all-cause mortality compared to achievement of either target Ca or iPTH levels.
Achieving target P + iPTH levels (OR 1.32) was associated with a lower odds ratio for all-cause mortality compared to achieving target Ca + P (OR 1.66) and Ca + iPTH (OR 1.43) levels.
Similar trends were observed for CV mortality risk.
Conclusions.
The present study demonstrated that achieving serum P levels within the KDIGO target range is the most important factor for lowering mortality in HD patients.
American Psychological Association (APA)
Liu, Ying& Lee, Wen-Chin& Cheng, Ben-Chung& Li, Lung-Chih& Lee, Chih-Hsiung& Chang, Wen-Xiu…[et al.]. 2016. Association between the Achievement of Target Range CKD-MBD Markers and Mortality in Prevalent Hemodialysis Patients in Taiwan by Using the Kidney Disease: Improving Global Outcomes Clinical Guidelines. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096907
Modern Language Association (MLA)
Liu, Ying…[et al.]. Association between the Achievement of Target Range CKD-MBD Markers and Mortality in Prevalent Hemodialysis Patients in Taiwan by Using the Kidney Disease: Improving Global Outcomes Clinical Guidelines. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096907
American Medical Association (AMA)
Liu, Ying& Lee, Wen-Chin& Cheng, Ben-Chung& Li, Lung-Chih& Lee, Chih-Hsiung& Chang, Wen-Xiu…[et al.]. Association between the Achievement of Target Range CKD-MBD Markers and Mortality in Prevalent Hemodialysis Patients in Taiwan by Using the Kidney Disease: Improving Global Outcomes Clinical Guidelines. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096907