Obstructive Form of Hypertrophic Cardiomyopathy-Left Ventricular Outflow Tract Gradient: Novel Methods of Provocation, Monitoring of Biomarkers, and Recent Advances in the Treatment
Joint Authors
Dimitrow, Pawel Petkow
Rajtar-Salwa, Renata
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Dynamic (latent or/and labile) obstruction of left ventricular outflow (LVOT) was recognized from the earliest clinical descriptions of hypertrophic cardiomyopathy (HCM) and has proved to be a complex phenomenon, as well as arguably the most audible (“visible”) pathophysiological hallmark of this heterogeneous disease.
The aim of the current review is focused on two novel issues in a subgroup of obstructive HCM.
Firstly, the important methodological problem in HCM is the examination of a subgroup of patients with nonobstructive hypertrophy in resting conditions and hard, but possible provoking obstruction.
Recently, investigators have proposed physiological stress test (with double combined stimuli) to disclose such type of patients.
The upright exercise is described in the ESC guideline on hypertrophic cardiomyopathy from 2014 and may appear as a candidate for gold standard provocation test.
The second novel area of interest is associated with elevated level of signaling biomarkers: hypercoagulation, hemolysis, acquired von Willebrand 2A disease, and enhanced oxidative stress.
The accelerated and turbulent flow within narrow LVOT may be responsible for these biochemical disturbances.
The most recent advances in the treatment of obstructive HCM are related to nonpharmacological methods of LVOT gradient reduction.
This report extensively discusses novel methods.
American Psychological Association (APA)
Dimitrow, Pawel Petkow& Rajtar-Salwa, Renata. 2016. Obstructive Form of Hypertrophic Cardiomyopathy-Left Ventricular Outflow Tract Gradient: Novel Methods of Provocation, Monitoring of Biomarkers, and Recent Advances in the Treatment. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096912
Modern Language Association (MLA)
Dimitrow, Pawel Petkow& Rajtar-Salwa, Renata. Obstructive Form of Hypertrophic Cardiomyopathy-Left Ventricular Outflow Tract Gradient: Novel Methods of Provocation, Monitoring of Biomarkers, and Recent Advances in the Treatment. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096912
American Medical Association (AMA)
Dimitrow, Pawel Petkow& Rajtar-Salwa, Renata. Obstructive Form of Hypertrophic Cardiomyopathy-Left Ventricular Outflow Tract Gradient: Novel Methods of Provocation, Monitoring of Biomarkers, and Recent Advances in the Treatment. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096912