Role of miRNAs in Epicardial Adipose Tissue in CAD Patients with T2DM
Joint Authors
Fu, Wenbo
Wei, Yutao
Liu, Yang
Lu, Mu
Huai, Shitao
Song, Yaqin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Epicardial adipose tissue (EAT) is identified as an atypical fat depot surrounding the heart with a putative role in the involvement of metabolic disorders, including obesity, type-2 diabetes mellitus, and atherosclerosis.
We profiled miRNAs in EAT of metabolic patients with coronary artery disease (CAD) and type-2 diabetes mellitus (T2DM) versus metabolically healthy patients by microarray.
Compared to metabolically healthy patients, we identified forty-two miRNAs that are differentially expressed in patients with CAD and T2DM from Xinjiang, China.
Eleven miRNAs were selected as potential novel miRNAs according to P value and fold change.
Then the potential novel miRNAs targeted genes were predicted via TargetScan, PicTar, and miRTarbase, and the function of the target genes was predicted via Gene Ontology (GO) analysis while the enriched KEGG pathway analyses of the miRNAs targeted genes were performed by bioinformatics software DAVID.
Then protein-protein interaction networks of the targeted gene were conducted by online software STRING.
Finally, using microarray, bioinformatics approaches revealed the possible molecular mechanisms pathogenesis of CAD and T2DM.
A total of 11 differentially expressed miRNAs were identified and among them, hsa-miR-4687-3p drew specific attention.
Bioinformatics analysis revealed that insulin signaling pathway is the central way involved in the progression of metabolic disorders.
Conclusions.
The current findings support the fact that miRNAs are involved in the pathogenesis of metabolic disorders in EAT of CAD patients with T2DM, and validation of the results of these miRNAs by independent and prospective study is certainly warranted.
American Psychological Association (APA)
Liu, Yang& Fu, Wenbo& Lu, Mu& Huai, Shitao& Song, Yaqin& Wei, Yutao. 2016. Role of miRNAs in Epicardial Adipose Tissue in CAD Patients with T2DM. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096924
Modern Language Association (MLA)
Liu, Yang…[et al.]. Role of miRNAs in Epicardial Adipose Tissue in CAD Patients with T2DM. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096924
American Medical Association (AMA)
Liu, Yang& Fu, Wenbo& Lu, Mu& Huai, Shitao& Song, Yaqin& Wei, Yutao. Role of miRNAs in Epicardial Adipose Tissue in CAD Patients with T2DM. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096924