Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli
Joint Authors
Shi, Jingsong
Liu, Zhihong
Jiang, Song
Qiu, Dandan
Le, Weibo
Wang, Xiao
Lu, Yinhui
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
To investigate potential drugs for diabetic nephropathy (DN) using whole-genome expression profiles and the Connectivity Map (CMAP).
Methodology.
Eighteen Chinese Han DN patients and six normal controls were included in this study.
Whole-genome expression profiles of microdissected glomeruli were measured using the Affymetrix human U133 plus 2.0 chip.
Differentially expressed genes (DEGs) between late stage and early stage DN samples and the CMAP database were used to identify potential drugs for DN using bioinformatics methods.
Results.
(1) A total of 1065 DEGs (FDR < 0.05 and fold change > 1.5) were found in late stage DN patients compared with early stage DN patients.
(2) Piperlongumine, 15d-PGJ2 (15-delta prostaglandin J2), vorinostat, and trichostatin A were predicted to be the most promising potential drugs for DN, acting as NF-κB inhibitors, histone deacetylase inhibitors (HDACIs), PI3K pathway inhibitors, or PPARγ agonists, respectively.
Conclusion.
Using whole-genome expression profiles and the CMAP database, we rapidly predicted potential DN drugs, and therapeutic potential was confirmed by previously published studies.
Animal experiments and clinical trials are needed to confirm both the safety and efficacy of these drugs in the treatment of DN.
American Psychological Association (APA)
Shi, Jingsong& Jiang, Song& Qiu, Dandan& Le, Weibo& Wang, Xiao& Lu, Yinhui…[et al.]. 2016. Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1096927
Modern Language Association (MLA)
Shi, Jingsong…[et al.]. Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1096927
American Medical Association (AMA)
Shi, Jingsong& Jiang, Song& Qiu, Dandan& Le, Weibo& Wang, Xiao& Lu, Yinhui…[et al.]. Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1096927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096927