The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis
Joint Authors
Huang, Shishu
Pan, Haobo
Lu, Weijia William
Sun, Mengge
Zhou, Xiaoya
Chen, Lili
Leung, Victor
Wu, Nan
Zhen, Wanxin
Peng, Songlin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
MicroRNAs are involved in many cellular and molecular activities and played important roles in many biological and pathological processes, such as tissue formation, cancer development, diabetes, neurodegenerative diseases, and cardiovascular diseases.
Recently, it has been reported that microRNAs can modulate the differentiation and activities of osteoblasts and osteoclasts, the key cells that are involved in bone remodeling process.
Meanwhile, the results from our and other research groups showed that the expression profiles of microRNAs in the serum and bone tissues are significantly different in postmenopausal women with or without fractures compared to the control.
Therefore, it can be postulated that microRNAs might play important roles in bone remodeling and that they are very likely to be involved in the pathological process of postmenopausal osteoporosis.
In this review, we will present the updated research on the regulatory roles of microRNAs in osteoblasts and osteoclasts and the expression profiles of microRNAs in osteoporosis and osteoporotic fracture patients.
The perspective of serum microRNAs as novel biomarkers in bone loss disorders such as osteoporosis has also been discussed.
American Psychological Association (APA)
Sun, Mengge& Zhou, Xiaoya& Chen, Lili& Huang, Shishu& Leung, Victor& Wu, Nan…[et al.]. 2016. The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096930
Modern Language Association (MLA)
Sun, Mengge…[et al.]. The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1096930
American Medical Association (AMA)
Sun, Mengge& Zhou, Xiaoya& Chen, Lili& Huang, Shishu& Leung, Victor& Wu, Nan…[et al.]. The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096930