![](/images/graphics-bg.png)
Predicted 3D Model of the Rabies Virus Glycoprotein Trimer
Joint Authors
Correa Basurto, Jose
Fernando, Bastida-González
Yersin, Celaya-Trejo
Paola, Zárate-Segura
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The RABVG ectodomain is a homotrimer, and trimers are often called spikes.
They are responsible for the attachment of the virus through the interaction with nicotinic acetylcholine receptors, neural cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR).
This makes them relevant in viral pathogenesis.
The antigenic structure differs significantly between the trimers and monomers.
Surfaces rich in hydrophobic amino acids are important for trimer stabilization in which the C-terminal of the ectodomain plays an important role; to understand these interactions between the G proteins, a mechanistic study of their functions was performed with a molecular model of G protein in its trimeric form.
This verified its 3D conformation.
The molecular modeling of G protein was performed by a I-TASSER server and was evaluated via a Rachamandran plot and ERRAT program obtained 84.64% and 89.9% of the residues in the favorable regions and overall quality factor, respectively.
The molecular dynamics simulations were carried out on RABVG trimer at 310 K.
From these theoretical studies, we retrieved the RMSD values from Cα atoms to assess stability.
Preliminary model of G protein of rabies virus stable at 12 ns with molecular dynamics was obtained.
American Psychological Association (APA)
Fernando, Bastida-González& Yersin, Celaya-Trejo& Correa Basurto, Jose& Paola, Zárate-Segura. 2016. Predicted 3D Model of the Rabies Virus Glycoprotein Trimer. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096933
Modern Language Association (MLA)
Fernando, Bastida-González…[et al.]. Predicted 3D Model of the Rabies Virus Glycoprotein Trimer. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1096933
American Medical Association (AMA)
Fernando, Bastida-González& Yersin, Celaya-Trejo& Correa Basurto, Jose& Paola, Zárate-Segura. Predicted 3D Model of the Rabies Virus Glycoprotein Trimer. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1096933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096933