Study of Antiobesity Effect through Inhibition of Pancreatic Lipase Activity of Diospyros kaki Fruit and Citrus unshiu Peel
Joint Authors
Lee, Joo Young
Shin, Yu Ock
Kim, Gyo-Nam
Shin, Sung Ho
Lee, Ah Reum
Seo, Bu-Il
Kim, Min Yeong
Kim, Tae Hoon
Noh, Jeong Sook
Rhee, Man Hee
Roh, Seong-Soo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Pancreatic lipase is the enzyme responsible for digestion and absorption of triglycerides, being its inhibition one of the widest studied methods used to determine the potential activity of natural products to inhibit dietary fat absorption.
Decrease of energy intake from dietary fat through inhibition of this enzyme may be an excellent strategy to prevent and treat obesity.
The inhibitory activity on pancreatic lipase enzyme of Diospyros kaki fruit and Citrus unshiu peel mixture extract (PCM) was evaluated in vitro and its antiobesity effects were studied based on the serum lipid parameters analysis from high-fat diet- (HFD-) fed mice in vivo.
PCM was orally administered at a dose of 50 and 200 mg/kg body weight for 6 weeks.
In addition, the activity of pancreatic lipase was assessed using orlistat (positive control).
PCM exhibited inhibitory effect on lipase activity with IC50 value of 507.01 μg/mL.
Moreover, serum triacylglycerol, total cholesterol levels, and visceral fat weight were significantly reduced compared to HFD control mice in PCM 200 mg/kg-treated mice ( p < 0.05 ).
These results suggest that PCM administration may be a novel potential antiobesity agent for reduction of fat absorption via inhibition of pancreatic lipase.
American Psychological Association (APA)
Kim, Gyo-Nam& Shin, Yu Ock& Shin, Sung Ho& Lee, Ah Reum& Lee, Joo Young& Seo, Bu-Il…[et al.]. 2016. Study of Antiobesity Effect through Inhibition of Pancreatic Lipase Activity of Diospyros kaki Fruit and Citrus unshiu Peel. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096945
Modern Language Association (MLA)
Kim, Gyo-Nam…[et al.]. Study of Antiobesity Effect through Inhibition of Pancreatic Lipase Activity of Diospyros kaki Fruit and Citrus unshiu Peel. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096945
American Medical Association (AMA)
Kim, Gyo-Nam& Shin, Yu Ock& Shin, Sung Ho& Lee, Ah Reum& Lee, Joo Young& Seo, Bu-Il…[et al.]. Study of Antiobesity Effect through Inhibition of Pancreatic Lipase Activity of Diospyros kaki Fruit and Citrus unshiu Peel. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096945