Proapoptotic Role of Potassium Ions in Liver Cells
Joint Authors
Xia, Zhenglin
Huang, Xusen
Chen, Kaiyun
Wang, Hanning
Xiao, Jinfeng
He, Ke
Huang, Rui
Duan, Xiaopeng
Liu, Hao
Zhang, Jinqian
Xiang, Guoan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Potassium channels are transmembrane proteins that selectively promote the infiltration of potassium ions.
The significance of these channels for tumor biology has become obvious.
However, the effects of potassium ions on the tumor or normal cells have seldom been studied.
To address this problem, we studied the biological effects of L02 and HepG2 cells with ectogenous potassium ions.
Cell proliferation, cell cycle, and apoptosis rate were analyzed.
Our results indicated that potassium ions inhibited proliferation of L02 and HepG2 cells and promoted their apoptosis.
Potassium ions induced apoptosis through regulating Bcl-2 family members and depolarized the mitochondrial membrane, especially for HepG2 cell.
These biological effects were associated with channel protein HERG.
By facilitating expression of channel protein HERG, potassium ions may prevent it from being shunted to procancerous pathways by inducing apoptosis.
These results demonstrated that potassium ions may be a key regulator of liver cell function.
Thus, our findings suggest that potassium ions could inhibit tumorigenesis through inducing apoptosis of hepatoma cells by upregulating potassium ions transport channel proteins HERG and VDAC1.
American Psychological Association (APA)
Xia, Zhenglin& Huang, Xusen& Chen, Kaiyun& Wang, Hanning& Xiao, Jinfeng& He, Ke…[et al.]. 2016. Proapoptotic Role of Potassium Ions in Liver Cells. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096949
Modern Language Association (MLA)
Xia, Zhenglin…[et al.]. Proapoptotic Role of Potassium Ions in Liver Cells. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1096949
American Medical Association (AMA)
Xia, Zhenglin& Huang, Xusen& Chen, Kaiyun& Wang, Hanning& Xiao, Jinfeng& He, Ke…[et al.]. Proapoptotic Role of Potassium Ions in Liver Cells. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096949