Serum Procalcitonin and Procalcitonin Clearance as a Prognostic Biomarker in Patients with Severe Sepsis and Septic Shock
Joint Authors
Wu, Kang-Hsi
Huang, Min-Yi
Chen, Chun-Yu
Chien, Ju-Huei
Wu, Kun-Hsi
Chang, Yu-Jun
Wu, Han P.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We evaluated the tendency of the plasma concentration and procalcitonin (PCT) clearance (PCTc) to act as biomarkers of prognosis in patients with severe sepsis and septic shock.
From 2011 to 2013, we prospectively analyzed patients with sepsis admitted to the intensive care unit (ICU).
The serum PCT was evaluated at the time of sepsis diagnosis and again after 48 h (day 3) and 96 h (day 5).
PCTc after 48 h (PCTc-day 3) and 96 h (PCTc-day 5) was also calculated to evaluate the prognostic value for survival in patients with sepsis.
A total of 48 patients were included.
Overall mortality was 16.7% (8 patients).
PCTc was higher in survivors than in nonsurvivors, with significant differences on day 3 and day 5 (p=0.033; p=0.002, resp.); however, serum PCT levels on day 1, day 3, and day 5 were not significant prognostic factors for survival.
The prognosis of patients with severe sepsis and septic shock may be associated with PCTc.
Dynamic changes of PCT reflected as PCTc at 48 h (day 3) and 96 h (day 5) after admission to the ICU may serve as a predictor of survival in critically ill patients with severe sepsis.
American Psychological Association (APA)
Huang, Min-Yi& Chen, Chun-Yu& Chien, Ju-Huei& Wu, Kun-Hsi& Chang, Yu-Jun& Wu, Kang-Hsi…[et al.]. 2016. Serum Procalcitonin and Procalcitonin Clearance as a Prognostic Biomarker in Patients with Severe Sepsis and Septic Shock. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1096959
Modern Language Association (MLA)
Huang, Min-Yi…[et al.]. Serum Procalcitonin and Procalcitonin Clearance as a Prognostic Biomarker in Patients with Severe Sepsis and Septic Shock. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1096959
American Medical Association (AMA)
Huang, Min-Yi& Chen, Chun-Yu& Chien, Ju-Huei& Wu, Kun-Hsi& Chang, Yu-Jun& Wu, Kang-Hsi…[et al.]. Serum Procalcitonin and Procalcitonin Clearance as a Prognostic Biomarker in Patients with Severe Sepsis and Septic Shock. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1096959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096959