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A Two-Dimensional Numerical Investigation of Transport of Malaria-Infected Red Blood Cells in Stenotic Microchannels
Joint Authors
Tao, Yong
Rongin, Uwitije
Wang, Tong
Xing, Zhongwen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The malaria-infected red blood cells experience a significant decrease in cell deformability and increase in cell membrane adhesion.
Blood hemodynamics in microvessels is significantly affected by the alteration of the mechanical property as well as the aggregation of parasitized red blood cells.
In this study, we aim to numerically study the connection between cell-level mechanobiological properties of human red blood cells and related malaria disease state by investigating the transport of multiple red blood cell aggregates passing through microchannels with symmetric stenosis.
Effects of stenosis magnitude, aggregation strength, and cell deformability on cell rheology and flow characteristics were studied by a two-dimensional model using the fictitious domain-immersed boundary method.
The results indicated that the motion and dissociation of red blood cell aggregates were influenced by these factors and the flow resistance increases with the increase of aggregating strength and cell stiffness.
Further, the roughness of the velocity profile was enhanced by cell aggregation, which considerably affected the blood flow characteristics.
The study may assist us in understanding cellular-level mechanisms in disease development.
American Psychological Association (APA)
Wang, Tong& Tao, Yong& Rongin, Uwitije& Xing, Zhongwen. 2016. A Two-Dimensional Numerical Investigation of Transport of Malaria-Infected Red Blood Cells in Stenotic Microchannels. BioMed Research International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1096970
Modern Language Association (MLA)
Wang, Tong…[et al.]. A Two-Dimensional Numerical Investigation of Transport of Malaria-Infected Red Blood Cells in Stenotic Microchannels. BioMed Research International No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1096970
American Medical Association (AMA)
Wang, Tong& Tao, Yong& Rongin, Uwitije& Xing, Zhongwen. A Two-Dimensional Numerical Investigation of Transport of Malaria-Infected Red Blood Cells in Stenotic Microchannels. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1096970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096970