The Association between Abnormal Long Noncoding RNA MALAT-1 Expression and Cancer Lymph Node Metastasis: A Meta-Analysis
Joint Authors
Qin, Chao
Pan, Yongsheng
Wu, Jie
Zhang, Cheng
Huang, Yuan
Zhao, Ruizhe
Cheng, Gong
Liu, Jinliang
Shao, Pengfei
Hua, Lixin
Wang, Zengjun
Wang, Jun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Previous studies have investigated that the expression levels of MALAT-1 were higher in cancerous tissues than matched histologically normal tissues.
And, to some extent, overexpression of MALAT-1 was inclined to lymph node metastasis.
This meta-analysis collected all relevant articles and explored the association between MALAT-1 expression levels and lymph node metastasis.
We searched PubMed, EmBase, Web of Science, Cochrane Library, and OVID to address the level of MALAT-1 expression in cancer cases and noncancerous controls (accessed February 2015).
And 8 studies comprising 696 multiple cancer patients were included to assess this association.
The odds ratio (OR) and its corresponding 95% confidence interval (CI) were calculated to assess the strength of the association using Stata 12.0 version software.
The results revealed there was a significant difference in the incidence of lymph node metastasis between high MALAT-1 expression group and low MALAT-1 expression group (OR = 1.94, 95% CI 1.15–3.28, P = 0.0 13 random-effects model).
Subgroup analysis indicated that MALAT-1 high expression had an unfavorable impact on lymph node metastasis in Chinese patients (OR = 1.87, 95% CI 1.01–2.46).
This study demonstrated that the incidence of lymph node metastasis in patients detected with high MALAT-1 expression was higher than that in patients with low MALAT-1 expression in China.
American Psychological Association (APA)
Wang, Jun& Pan, Yongsheng& Wu, Jie& Zhang, Cheng& Huang, Yuan& Zhao, Ruizhe…[et al.]. 2016. The Association between Abnormal Long Noncoding RNA MALAT-1 Expression and Cancer Lymph Node Metastasis: A Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096977
Modern Language Association (MLA)
Wang, Jun…[et al.]. The Association between Abnormal Long Noncoding RNA MALAT-1 Expression and Cancer Lymph Node Metastasis: A Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096977
American Medical Association (AMA)
Wang, Jun& Pan, Yongsheng& Wu, Jie& Zhang, Cheng& Huang, Yuan& Zhao, Ruizhe…[et al.]. The Association between Abnormal Long Noncoding RNA MALAT-1 Expression and Cancer Lymph Node Metastasis: A Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096977