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Expression Profiling of Genes Related to Endothelial Cells Biology in Patients with Type 2 Diabetes and Patients with Prediabetes
Joint Authors
Ismail, Patimah
Moradipoor, Sara
Etemad, Ali
Wan Sulaiman, Wan Aliaa
Ahmadloo, Salma
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Endothelial dysfunction appears to be an early sign indicating vascular damage and predicts the progression of atherosclerosis and cardiovascular disorders.
Extensive clinical and experimental evidence suggests that endothelial dysfunction occurs in Type 2 Diabetes Mellitus (T2DM) and prediabetes patients.
This study was carried out with an aim to appraise the expression levels in the peripheral blood of 84 genes related to endothelial cells biology in patients with diagnosed T2DM or prediabetes, trying to identify new genes whose expression might be changed under these pathological conditions.
The study covered a total of 45 participants.
The participants were divided into three groups: group 1, patients with T2DM; group 2, patients with prediabetes; group 3, control group.
The gene expression analysis was performed using the Endothelial Cell Biology RT2 Profiler PCR Array.
In the case of T2DM, 59 genes were found to be upregulated, and four genes were observed to be downregulated.
In prediabetes patients, increased expression was observed for 49 genes, with two downregulated genes observed.
Our results indicate that diabetic and prediabetic conditions change the expression levels of genes related to endothelial cells biology and, consequently, may increase the risk for occurrence of endothelial dysfunction.
American Psychological Association (APA)
Moradipoor, Sara& Ismail, Patimah& Etemad, Ali& Wan Sulaiman, Wan Aliaa& Ahmadloo, Salma. 2016. Expression Profiling of Genes Related to Endothelial Cells Biology in Patients with Type 2 Diabetes and Patients with Prediabetes. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096981
Modern Language Association (MLA)
Moradipoor, Sara…[et al.]. Expression Profiling of Genes Related to Endothelial Cells Biology in Patients with Type 2 Diabetes and Patients with Prediabetes. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1096981
American Medical Association (AMA)
Moradipoor, Sara& Ismail, Patimah& Etemad, Ali& Wan Sulaiman, Wan Aliaa& Ahmadloo, Salma. Expression Profiling of Genes Related to Endothelial Cells Biology in Patients with Type 2 Diabetes and Patients with Prediabetes. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1096981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096981