The Role of BRCA2 Mutation Status as Diagnostic, Predictive, and Prognosis Biomarker for Pancreatic Cancer
Joint Authors
Martinez-Useros, Javier
Garcia-Foncillas, Jesus
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pancreatic cancer is one of the deadliest cancers worldwide, and life expectancy after diagnosis is often short.
Most pancreatic tumours appear sporadically and have been highly related to habits such as cigarette smoking, high alcohol intake, high carbohydrate, and sugar consumption.
Other observational studies have suggested the association between pancreatic cancer and exposure to arsenic, lead, or cadmium.
Aside from these factors, chronic pancreatitis and diabetes have also come to be considered as risk factors for these kinds of tumours.
Studies have found that 10% of pancreatic cancer cases arise from an inherited syndrome related to some genetic alterations.
One of these alterations includes mutation in BRCA2 gene.
BRCA2 mutations impair DNA damage response and homologous recombination by direct regulation of RAD51.
In light of these findings that link genetic factors to tumour development, DNA damage agents have been proposed as target therapies for pancreatic cancer patients carrying BRCA2 mutations.
Some of these drugs include platinum-based agents and PARP inhibitors.
However, the acquired resistance to PARP inhibitors has created a need for new chemotherapeutic strategies to target BRCA2.
The present systematic review collects and analyses the role of BRCA2 alterations to be used in early diagnosis of an inherited syndrome associated with familiar cancer and as a prognostic and predictive biomarker for the management of pancreatic cancer patients.
American Psychological Association (APA)
Martinez-Useros, Javier& Garcia-Foncillas, Jesus. 2016. The Role of BRCA2 Mutation Status as Diagnostic, Predictive, and Prognosis Biomarker for Pancreatic Cancer. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096988
Modern Language Association (MLA)
Martinez-Useros, Javier& Garcia-Foncillas, Jesus. The Role of BRCA2 Mutation Status as Diagnostic, Predictive, and Prognosis Biomarker for Pancreatic Cancer. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096988
American Medical Association (AMA)
Martinez-Useros, Javier& Garcia-Foncillas, Jesus. The Role of BRCA2 Mutation Status as Diagnostic, Predictive, and Prognosis Biomarker for Pancreatic Cancer. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096988