The Role of the Transcription Factor Foxo3 in Hearing Maintenance: Informed Speculation on a New Player in the Cochlea
Author
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Molecular genetics has proven to be a powerful approach for understanding early-onset hearing loss.
Recent work in late-onset hearing loss uses mouse genetics to identify molecular mechanisms that promote the maintenance of hearing.
One such gene, Foxo3, is ontologically involved in preserving mitochondrial function.
Significant evidence exists to support the idea that mitochondrial dysfunction is correlated with and can be causal for hearing loss.
Foxo3 is also ontologically implicated in driving the circadian cycle, which has recently been shown to influence the molecular response to noise damage.
In this review, the molecular framework connecting these cellular processes is discussed in relation to the cellular pathologies observed in human specimens of late-onset hearing loss.
In bringing these observations together, the possibility arises that distinct molecular mechanisms work in multiple cell types to preserve hearing.
This diversity offers great opportunities to understand and manipulate genetic processes for therapeutic gain.
American Psychological Association (APA)
White, Patricia M.. 2016. The Role of the Transcription Factor Foxo3 in Hearing Maintenance: Informed Speculation on a New Player in the Cochlea. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096989
Modern Language Association (MLA)
White, Patricia M.. The Role of the Transcription Factor Foxo3 in Hearing Maintenance: Informed Speculation on a New Player in the Cochlea. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1096989
American Medical Association (AMA)
White, Patricia M.. The Role of the Transcription Factor Foxo3 in Hearing Maintenance: Informed Speculation on a New Player in the Cochlea. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096989