Gender-Specific Association of ATP2B1 Variants with Susceptibility to Essential Hypertension in the Han Chinese Population
Joint Authors
Xu, Jin
Ji, Lin-dan
Qian, Hai-xia
Hu, Su-pei
Liu, Li-ya
Zhou, Mi
Feng, Mei
Su, Jia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Previous genome-wide association studies (GWASs) found that several ATP2B1 variants are associated with essential hypertension (EHT).
But the “genome-wide significant” ATP2B1 SNPs (rs2681472, rs2681492, rs17249754, and rs1105378) are in strong linkage disequilibrium (LD) and are located in the same LD block in Chinese populations.
We asked whether there are other SNPs within the ATP2B1 gene associated with susceptibility to EHT in the Han Chinese population.
Therefore, we performed a case-control study to investigate the association of seven tagSNPs within the ATP2B1 gene and EHT in the Han Chinese population, and we then analyzed the interaction among different SNPs and nongenetic risk factors for EHT.
A total of 902 essential hypertensive cases and 902 normotensive controls were involved in the study.
All 7 tagSNPs within the ATP2B1 gene were retrieved from HapMap, and genotyping was performed using the Tm-shift genotyping method.
Chi-squared test, logistic regression, and propensity score analysis showed that rs17249754 was associated with EHT, particularly in females.
The MDR analysis demonstrated that the interaction of rs2070759, rs17249754, TC, TG, and BMI increased the susceptibility to hypertension.
Crossover analysis and stratified analysis indicated that BMI has a major effect on the development of hypertension, while ATP2B1 variants have a minor effect.
American Psychological Association (APA)
Xu, Jin& Qian, Hai-xia& Hu, Su-pei& Liu, Li-ya& Zhou, Mi& Feng, Mei…[et al.]. 2016. Gender-Specific Association of ATP2B1 Variants with Susceptibility to Essential Hypertension in the Han Chinese Population. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096996
Modern Language Association (MLA)
Xu, Jin…[et al.]. Gender-Specific Association of ATP2B1 Variants with Susceptibility to Essential Hypertension in the Han Chinese Population. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096996
American Medical Association (AMA)
Xu, Jin& Qian, Hai-xia& Hu, Su-pei& Liu, Li-ya& Zhou, Mi& Feng, Mei…[et al.]. Gender-Specific Association of ATP2B1 Variants with Susceptibility to Essential Hypertension in the Han Chinese Population. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096996