Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNKERK MAPK Pathways
Joint Authors
Yu, Huang-Ping
Liu, Fu-Chao
Lee, Hung-Chen
Liao, Chia-Chih
Li, Allen H.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
To investigate the protective effects of tropisetron on acetaminophen- (APAP-) induced liver injury in a mice model.
Methods.
C57BL/6 male mice were given tropisetron (0.3 to 10 mg/kg) 30 minutes before a hepatotoxic dose of acetaminophen (300 mg/kg) intraperitoneally.
Twenty hours after APAP intoxication, sera alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, hepatic myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) activities, and liver histopathological changes were examined.
The MAP kinases were also detected by western blotting.
Results.
Our results showed that tropisetron pretreatment significantly attenuated the acute elevations of the liver enzyme ALT level, hepatic MPO activity, and hepatocytes necrosis in a dose-dependent manner (0.3–10 mg/kg) in APAP-induced hepatotoxicity mice.
Tropisetron (1 and 3 mg/kg) suppressed APAP-induced hepatic lipid peroxidation expression and alleviated GSH and SOD depletion.
Administration of tropisetron also attenuated the phosphorylation of c-Jun-NH2-terminal protein kinase (JNK) and extracellular signal-regulated kinase (ERK) caused by APAP.
Conclusion.
Our data demonstrated that tropisetron’s hepatoprotective effect was in part correlated with the antioxidant, which were mediated via JNK and ERK pathways on acetaminophen-induced liver injury in mice.
American Psychological Association (APA)
Liu, Fu-Chao& Lee, Hung-Chen& Liao, Chia-Chih& Li, Allen H.& Yu, Huang-Ping. 2016. Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNKERK MAPK Pathways. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097002
Modern Language Association (MLA)
Liu, Fu-Chao…[et al.]. Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNKERK MAPK Pathways. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097002
American Medical Association (AMA)
Liu, Fu-Chao& Lee, Hung-Chen& Liao, Chia-Chih& Li, Allen H.& Yu, Huang-Ping. Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNKERK MAPK Pathways. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097002