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Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance
Joint Authors
Engineer, Nikita
Kasembeli, Moses
Bharadwaj, Uddalak
Eckols, Kris T.
Tweardy, David J.
Robinson, Prema
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Doxorubicin (DOX), an anthracycline, is broadly considered the most active single agent available for treating breast cancer but has been known to induce cardiotoxicity.
Although DOX is highly effective in treating triple-negative breast cancer (TNBC), DOX can have poor outcomes owing to induction of chemoresistance.
There is an urgent need to develop new therapies for TNBC aimed at improving DOX outcome and DOX-induced cardiotoxicity.
Substance P (SP), a neuropeptide involved in pain transmission is known to stimulate production of reactive oxygen species (ROS).
Elevated cardiac ROS is linked with heart injury and failure.
We investigated the role of SP in chemotherapy-associated death of cardiomyocytes and chemoresistance.
We showed that pretreating a cardiomyocyte cell line (H9C2) and a TNBC cell line (MDA-MB 231) with aprepitant, a SP receptor antagonist that is routinely used to treat chemotherapy-associated associated nausea, decreased DOX-induced reduction of cell viability, apoptotic cell death, and ROS production in cardiomyocytes and increased DOX-induced reduction of cell viability, apoptotic cell death, and ROS production in TNBC cells compared with cells treated with DOX alone.
Our findings demonstrate the ability of aprepitant to decrease DOX-induced killing of cardiomyocytes and to increase cancer cell sensitivity to DOX, which has tremendous clinical significance.
American Psychological Association (APA)
Robinson, Prema& Kasembeli, Moses& Bharadwaj, Uddalak& Engineer, Nikita& Eckols, Kris T.& Tweardy, David J.. 2016. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097006
Modern Language Association (MLA)
Robinson, Prema…[et al.]. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097006
American Medical Association (AMA)
Robinson, Prema& Kasembeli, Moses& Bharadwaj, Uddalak& Engineer, Nikita& Eckols, Kris T.& Tweardy, David J.. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097006