Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates
Joint Authors
van den Anker, Johannes N.
Samardzic, Janko
Smits, Anne
Spriet, Isabel
Soldatovic, Ivan
Atkinson, Andrew
Bajcetic, Milica
Allegaert, Karel
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-21
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Substantial interassay variability (up to 20%) has been described for vancomycin immunoassays in adults, but the impact of neonatal matrix is difficult to quantify because of blood volume constraints in neonates.
However, we provide circumstantial evidence for a similar extent of variability.
Using the same vancomycin dosing regimens and confirming similarity in clinical characteristics, vancomycin trough concentrations measured by PETINIA (2011-2012, n = 400 ) were 20% lower and the mean difference was 1.93 mg/L compared to COBAS (2012–2014, n = 352 ) measurements.
The impact of vancomycin immunoassays in neonatal matrix was hereby suggested, supporting a switch to more advanced techniques (LC-MS/MS).
American Psychological Association (APA)
Samardzic, Janko& Smits, Anne& Spriet, Isabel& Soldatovic, Ivan& Atkinson, Andrew& Bajcetic, Milica…[et al.]. 2016. Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates. BioMed Research International،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1097009
Modern Language Association (MLA)
Samardzic, Janko…[et al.]. Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates. BioMed Research International No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1097009
American Medical Association (AMA)
Samardzic, Janko& Smits, Anne& Spriet, Isabel& Soldatovic, Ivan& Atkinson, Andrew& Bajcetic, Milica…[et al.]. Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1097009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097009