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Utilizing Autologous Multipotent Mesenchymal Stromal Cells and β-Tricalcium Phosphate Scaffold in Human Bone Defects: A Prospective, Controlled Feasibility Trial
Joint Authors
Palicka, Vladimir
Šponer, Pavel
Kučera, Tomáš
Brtková, Jindra
Urban, Karel
Kočí, Zuzana
Syka, Michael
Syková, Eva
Bezrouk, Aleš
Filip, S.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The purpose of this prospective controlled study was to compare healing quality following the implantation of ultraporous β-tricalcium phosphate, containing either expanded autologous mesenchymal stromal cells (trial group, 9 patients) or β-tricalcium phosphate alone (control group, 9 patients), into femoral defects during revision total hip arthroplasty.
Both groups were assessed using the Harris Hip Score, radiography, and DEXA scanning at 6 weeks and 3, 6, and 12 months postoperatively.
A significant difference in the bone defect healing was observed between both groups of patients (P<0.05).
In the trial group, trabecular remodeling was found in all nine patients and in the control group, in 1 patient only.
Whereas, over the 12-month follow-up period, no significant difference was observed between both groups of patients in terms of the resorption of β-tricalcium phosphate, the significant differences were documented in the presence of radiolucency and bone trabeculation through the defect (P<0.05).
Using autologous mesenchymal stromal cells combined with a β-tricalcium phosphate scaffold is a feasible, safe, and effective approach for management of bone defects with compromised microenvironment.
The clinical trial was registered at the EU Clinical Trials Register before patient recruitment has begun (EudraCT number 2012-005599-33).
American Psychological Association (APA)
Šponer, Pavel& Filip, S.& Kučera, Tomáš& Brtková, Jindra& Urban, Karel& Palicka, Vladimir…[et al.]. 2016. Utilizing Autologous Multipotent Mesenchymal Stromal Cells and β-Tricalcium Phosphate Scaffold in Human Bone Defects: A Prospective, Controlled Feasibility Trial. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097028
Modern Language Association (MLA)
Šponer, Pavel…[et al.]. Utilizing Autologous Multipotent Mesenchymal Stromal Cells and β-Tricalcium Phosphate Scaffold in Human Bone Defects: A Prospective, Controlled Feasibility Trial. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1097028
American Medical Association (AMA)
Šponer, Pavel& Filip, S.& Kučera, Tomáš& Brtková, Jindra& Urban, Karel& Palicka, Vladimir…[et al.]. Utilizing Autologous Multipotent Mesenchymal Stromal Cells and β-Tricalcium Phosphate Scaffold in Human Bone Defects: A Prospective, Controlled Feasibility Trial. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097028