Uncovering Driver DNA Methylation Events in Nonsmoking Early Stage Lung Adenocarcinoma
Joint Authors
Zhang, Xindong
Gao, Lin
Liu, Zhi-Ping
Jia, Songwei
Chen, Luonan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
As smoking rates decrease, proportionally more cases with lung adenocarcinoma occur in never-smokers, while aberrant DNA methylation has been suggested to contribute to the tumorigenesis of lung adenocarcinoma.
It is extremely difficult to distinguish which genes play key roles in tumorigenic processes via DNA methylation-mediated gene silencing from a large number of differentially methylated genes.
By integrating gene expression and DNA methylation data, a pipeline combined with the differential network analysis is designed to uncover driver methylation genes and responsive modules, which demonstrate distinctive expressions and network topology in tumors with aberrant DNA methylation.
Totally, 135 genes are recognized as candidate driver genes in early stage lung adenocarcinoma and top ranked 30 genes are recognized as driver methylation genes.
Functional annotation and the differential network analysis indicate the roles of identified driver genes in tumorigenesis, while literature study reveals significant correlations of the top 30 genes with early stage lung adenocarcinoma in never-smokers.
The analysis pipeline can also be employed in identification of driver epigenetic events for other cancers characterized by matched gene expression data and DNA methylation data.
American Psychological Association (APA)
Zhang, Xindong& Gao, Lin& Liu, Zhi-Ping& Jia, Songwei& Chen, Luonan. 2016. Uncovering Driver DNA Methylation Events in Nonsmoking Early Stage Lung Adenocarcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097032
Modern Language Association (MLA)
Zhang, Xindong…[et al.]. Uncovering Driver DNA Methylation Events in Nonsmoking Early Stage Lung Adenocarcinoma. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1097032
American Medical Association (AMA)
Zhang, Xindong& Gao, Lin& Liu, Zhi-Ping& Jia, Songwei& Chen, Luonan. Uncovering Driver DNA Methylation Events in Nonsmoking Early Stage Lung Adenocarcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097032
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097032