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Syntaxin 5 Overexpression and β-Amyloid 1–42 Accumulation in Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by Ozone Exposure
Joint Authors
Rivas-Arancibia, Selva
Hernández-Zimbrón, Luis Fernando
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress is a risk factor for Alzheimer’s disease and it is currently accepted that oxidative damage precedes the overproduction of A42 peptide.
We have reported that ozone causes oxidative stress inducing neurodegeneration in the brain of rats.
It is associated with A42 overproduction and intracellular accumulation in hippocampus.
Organelles like mitochondria, intracellular membranes, and endoplasmic reticulum have been identified as sites of A42 production and accumulation affecting cellular metabolism.
However whether ozone exposure induces overproduction and/or accumulation of A42 in endoplasmic reticulum has not been studied.
We evaluated this effect in the endoplasmic reticulum of hippocampal cells of rats exposed chronically to low doses of ozone (0.25 ppm) at 7, 15, 30, 60, and 90 days.
The effect of the presence of A42 in endoplasmic reticulum was analyzed evaluating the expression of the chaperone Syntaxin 5.
Our results show an accumulation of A42 peptide in this organelle.
It was observed by immunofluorescence and by WB in endoplasmic fractions from hippocampal cells of rats at 60 and 90 days of treatment.
Significant overexpression of the chaperone Syntaxin 5 at 60 and 90 days of treatment was observed ( P ⁎ < 0.05 ).
These results indicate that the exposure to environmental pollutants could be involved as a risk factor for neurodegenerative processes.
American Psychological Association (APA)
Hernández-Zimbrón, Luis Fernando& Rivas-Arancibia, Selva. 2016. Syntaxin 5 Overexpression and β-Amyloid 1–42 Accumulation in Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by Ozone Exposure. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097036
Modern Language Association (MLA)
Hernández-Zimbrón, Luis Fernando& Rivas-Arancibia, Selva. Syntaxin 5 Overexpression and β-Amyloid 1–42 Accumulation in Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by Ozone Exposure. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097036
American Medical Association (AMA)
Hernández-Zimbrón, Luis Fernando& Rivas-Arancibia, Selva. Syntaxin 5 Overexpression and β-Amyloid 1–42 Accumulation in Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by Ozone Exposure. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097036