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Immunologic Changes Implicated in the Pathogenesis of Focal Segmental Glomerulosclerosis
Joint Authors
Kronbichler, Andreas
Leierer, Johannes
Oh, Jun
Meijers, Björn
Shin, Jae Il
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Focal segmental glomerulosclerosis is a histological pattern on renal biopsy caused by diverse mechanisms.
In its primary form, a circulatory factor is implicated in disease onset and recurrence.
The natural history of primary FSGS is unpredictable, since some patients are unresponsive towards immunosuppressive measures.
Immunologic changes, leading to a proinflammatory or profibrotic milieu, have been implicated in disease progression, namely, glomerular scarring, eventually leading to end-stage renal disease.
Among these, interleukin-1ß, tumor-necrosis factor-α (TNF-α), and transforming growth factor-ß1 (TGF-ß1) have emerged as important factors.
Translating these findings into clinical practice dampened the enthusiasm, since both TNF-α and TGF-ß1 blockade failed to achieve significant control of the disease.
More recently, a role of the complement system has been demonstrated which in fact may be another attractive target in clinical practice.
Rituximab, blocking CD20-bearing cells, demonstrated conflicting data regarding efficacy in FSGS.
Finally, the T-cell costimulating molecule B7-1 (CD80) is implicated in development of proteinuria in general.
Blockade of this target demonstrated significant benefits in a small cohort of resistant patients.
Taken together, this review focuses on immunology of FSGS, attributable to either the disease or progression, and discusses novel therapeutic approaches aiming at targeting immunologic factors.
American Psychological Association (APA)
Kronbichler, Andreas& Leierer, Johannes& Oh, Jun& Meijers, Björn& Shin, Jae Il. 2016. Immunologic Changes Implicated in the Pathogenesis of Focal Segmental Glomerulosclerosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097041
Modern Language Association (MLA)
Kronbichler, Andreas…[et al.]. Immunologic Changes Implicated in the Pathogenesis of Focal Segmental Glomerulosclerosis. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1097041
American Medical Association (AMA)
Kronbichler, Andreas& Leierer, Johannes& Oh, Jun& Meijers, Björn& Shin, Jae Il. Immunologic Changes Implicated in the Pathogenesis of Focal Segmental Glomerulosclerosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097041