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The In Vitro Lipolysis of Lipid-Based Drug Delivery Systems: A Newly Identified Relationship between Drug Release and Liquid Crystalline Phase
Joint Authors
Xiao, Lu
Yi, Tao
Liu, Ying
Zhou, Hua
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The purpose of this study was to offer a new insight into the microstructure changes during in vitro lipolysis of five lipid-based drug delivery formulations belonging to different lipid formulation types.
Five lipid-based formulations of indomethacin were investigated using an in vitro lipolysis model.
During lipolysis, microstructures of the intermediate phase formed by lipolytic products were observed.
The results showed that the time of liquid crystal formation during in vitro digestion for these formulations was Type I > Type II > Type IIIB > Type IV > Type IIIA ( p < 0.0 5 ).
After lipolysis, the drug releases from these formulations were determined.
The results showed that the amount of drug distributed in the aqueous phase, obtained by ultracentrifuge after lipolysis, was, astonishingly, in inverse rank order of the above mentioned, that is, Type IIIA > Type IV > Type IIIB > Type II > Type I ( p < 0.05 ).
These results showed that the liquid crystalline phase probably has a critical influence on the fate of the drug during in vitro lipolysis and suggested that the liquid crystalline phase facilitated drug precipitation.
These findings may improve the understanding of lipolysis of lipid-based drug delivery systems for designing better delivery system.
American Psychological Association (APA)
Xiao, Lu& Yi, Tao& Liu, Ying& Zhou, Hua. 2016. The In Vitro Lipolysis of Lipid-Based Drug Delivery Systems: A Newly Identified Relationship between Drug Release and Liquid Crystalline Phase. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097058
Modern Language Association (MLA)
Xiao, Lu…[et al.]. The In Vitro Lipolysis of Lipid-Based Drug Delivery Systems: A Newly Identified Relationship between Drug Release and Liquid Crystalline Phase. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097058
American Medical Association (AMA)
Xiao, Lu& Yi, Tao& Liu, Ying& Zhou, Hua. The In Vitro Lipolysis of Lipid-Based Drug Delivery Systems: A Newly Identified Relationship between Drug Release and Liquid Crystalline Phase. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097058