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Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue
Joint Authors
Wankhade, Umesh D.
Shen, Michael
Yadav, Hariom
Thakali, Keshari M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Nonshivering thermogenesis is the process of biological heat production in mammals and is primarily mediated by brown adipose tissue (BAT).
Through ubiquitous expression of uncoupling protein 1 (Ucp1) on the mitochondrial inner membrane, BAT displays uncoupling of fuel combustion and ATP production in order to dissipate energy as heat.
Because of its crucial role in regulating energy homeostasis, ongoing exploration of BAT has emphasized its therapeutic potential in addressing the global epidemics of obesity and diabetes.
The recent appreciation that adult humans possess functional BAT strengthens this prospect.
Furthermore, it has been identified that there are both classical brown adipocytes residing in dedicated BAT depots and “beige” adipocytes residing in white adipose tissue depots that can acquire BAT-like characteristics in response to environmental cues.
This review aims to provide a brief overview of BAT research and summarize recent findings concerning the physiological, cellular, and developmental characteristics of brown adipocytes.
In addition, some key genetic, molecular, and pharmacologic targets of BAT/Beige cells that have been reported to have therapeutic potential to combat obesity will be discussed.
American Psychological Association (APA)
Wankhade, Umesh D.& Shen, Michael& Yadav, Hariom& Thakali, Keshari M.. 2016. Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue. BioMed Research International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1097059
Modern Language Association (MLA)
Wankhade, Umesh D.…[et al.]. Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue. BioMed Research International No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1097059
American Medical Association (AMA)
Wankhade, Umesh D.& Shen, Michael& Yadav, Hariom& Thakali, Keshari M.. Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1097059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097059