Identifying Liver Cancer-Related Enhancer SNPs by Integrating GWAS and Histone Modification ChIP-seq Data
Joint Authors
Zhang, Tianjiao
Hu, Yang
Wu, Xiaoliang
Ma, Rui
Wang, Yadong
Jiang, Qinghua
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Many disease-related single nucleotide polymorphisms (SNPs) have been inferred from genome-wide association studies (GWAS) in recent years.
Numerous studies have shown that some SNPs located in protein-coding regions are associated with numerous diseases by affecting gene expression.
However, in noncoding regions, the mechanism of how SNPs contribute to disease susceptibility remains unclear.
Enhancer elements are functional segments of DNA located in noncoding regions that play an important role in regulating gene expression.
The SNPs located in enhancer elements may affect gene expression and lead to disease.
We presented a method for identifying liver cancer-related enhancer SNPs through integrating GWAS and histone modification ChIP-seq data.
We identified 22 liver cancer-related enhancer SNPs, 9 of which were regulatory SNPs involved in distal transcriptional regulation.
The results highlight that these enhancer SNPs may play important roles in liver cancer.
American Psychological Association (APA)
Zhang, Tianjiao& Hu, Yang& Wu, Xiaoliang& Ma, Rui& Jiang, Qinghua& Wang, Yadong. 2016. Identifying Liver Cancer-Related Enhancer SNPs by Integrating GWAS and Histone Modification ChIP-seq Data. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097064
Modern Language Association (MLA)
Zhang, Tianjiao…[et al.]. Identifying Liver Cancer-Related Enhancer SNPs by Integrating GWAS and Histone Modification ChIP-seq Data. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097064
American Medical Association (AMA)
Zhang, Tianjiao& Hu, Yang& Wu, Xiaoliang& Ma, Rui& Jiang, Qinghua& Wang, Yadong. Identifying Liver Cancer-Related Enhancer SNPs by Integrating GWAS and Histone Modification ChIP-seq Data. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097064