Association between Tumor Vasculogenic Mimicry and the Poor Prognosis of Gastric Cancer in China: An Updated Systematic Review and Meta-Analysis
Joint Authors
Guo, Qiujun
Li, Cong huang
Hou, Wei
Hua, Bao Jin
Gao, Yebo
Yuan, Yuan
Jin, Zhichao
Xu, Tao
Wei, Huamin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Vasculogenic mimicry can promote tumor growth and metastasis.
This article is aimed at conducting a systematic meta-analysis to explore the clinicopathological and prognostic significance of vasculogenic mimicry and gastric cancer.
Methods.
We searched Pubmed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and the VIP and Wanfang Database for eligible studies.
We manually searched for printed journals and relevant textbooks.
Subgroups analyses were performed based on the region, manuscript quality, methods of vasculogenic mimicry identification, pathology, and number of patients.
Results.
Nine studies with 997 patients were included in this meta-analysis.
A significant association was observed between vasculogenic mimicry-positive patients and those with gastric cancer with poor overall survival (hazard ratio = 2.24, 95% confidence interval: 1.45–3.47), poor pathological grading, high tumor node metastasis clinical stage, lymph node metastasis, deep tumor invasion, and distant metastasis.
Conclusions.
Vasculogenic mimicry is associated with a poor prognosis in patients with gastric cancer in China.
Clinical studies with large samples are needed worldwide and standardized protocols should be adopted in the future to achieve a better understanding of the relationship between gastric cancer and vasculogenic mimicry.
American Psychological Association (APA)
Guo, Qiujun& Yuan, Yuan& Jin, Zhichao& Xu, Tao& Gao, Yebo& Wei, Huamin…[et al.]. 2016. Association between Tumor Vasculogenic Mimicry and the Poor Prognosis of Gastric Cancer in China: An Updated Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097066
Modern Language Association (MLA)
Guo, Qiujun…[et al.]. Association between Tumor Vasculogenic Mimicry and the Poor Prognosis of Gastric Cancer in China: An Updated Systematic Review and Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1097066
American Medical Association (AMA)
Guo, Qiujun& Yuan, Yuan& Jin, Zhichao& Xu, Tao& Gao, Yebo& Wei, Huamin…[et al.]. Association between Tumor Vasculogenic Mimicry and the Poor Prognosis of Gastric Cancer in China: An Updated Systematic Review and Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097066